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XL-652

XL-652 Structure
XL-652
  • CAS No.918348-67-1
  • Chemical Name:XL-652
  • CBNumber:CB83146428
  • Molecular Formula:C28H29ClN2O3S
  • Formula Weight:509.06
  • MOL File:918348-67-1.mol
XL-652 Property
  • Boiling point 738.7±70.0 °C(Predicted)
  • Density 1.21±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO:65.0(Max Conc. mg/mL);127.69(Max Conc. mM)
    DMF:30.0(Max Conc. mg/mL);58.93(Max Conc. mM)
    Ethanol:30.0(Max Conc. mg/mL);58.93(Max Conc. mM)
  • form A crystalline solid
  • pka 13.56±0.29(Predicted)
  • color White to off-white
  • FDA UNII FB7ZTJ8M8A
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501

XL-652 Chemical Properties,Usage,Production

  • Uses BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.
  • in vivo

    BMS-779788 induces LXR target genes in blood in vivo with an EC50=610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B[1]. In mice BMS-779788 displays peripheral induction of ABCA1 at 3 and 10 mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2].

  • References [1] Kirchgessner TG, et al. Pharmacological characterization of a novel liver X receptor agonist with partial LXRα activity and a favorable window in nonhuman primates. J Pharmacol Exp Ther. 2015 Feb;352(2):305-14. DOI:10.1124/jpet.114.219923
    [2] Kick E, et al. Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ. Bioorg Med Chem Lett. 2015 Jan 15;25(2):372-7. DOI:10.1016/j.bmcl.2014.11.029
XL-652 Preparation Products And Raw materials
Raw materials
Preparation Products
XL-652 Suppliers
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XL-652 Spectrum
918348-67-1, XL-652Related Search:
  • 化合物XL652,10 MM DMSO 溶液
  • 2-[1-(2-氯苯基)-1-甲基乙基]-Α,Α二甲基-1-[3'-(甲基磺酰基)[1,1'-联苯]-4-基]-1H-咪唑-4-甲醇
  • 化合物XL652
  • 918348-67-1
  • BMS-779788, 10 mM in DMSO
  • 2-[1-(2-Chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-1H-imidazole-4-methanol
  • 2-{2-[2-(2-chlorophenyl)propan-2-yl]-1-{3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}-1H-imidazol-4-yl}propan-2-ol
  • Inhibitor,BMS779788,EXEL 04286652,Liver X receptor,inhibit,BMS 779788,LXR,BMS 788,BMS-779788,EXEL-04286652,BMS788
  • BMS 788
  • BMS-779788(XL-652)
  • BMS-779788; BMS 779788; BMS779788; BMS-788; BMS 788; BMS788; XL-652; XL652; XL652; EXEL 04286652; EXEL04286652; EXEL-04286652
  • BMS788
  • BMS-788
  • EXEL 04286652
  • 1H-Imidazole-4-methanol, 2-[1-(2-chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-
  • XL-652, >98%
  • BMS-779788, >98%
  • EXEL-04286652
  • EXEL04286652
  • BMS-779788
  • XL-652,BMS 779788
  • XL-652

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