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Insulin-like Growth Factor-1 Receptor Inhibitor

Insulin-like Growth Factor-1 Receptor Inhibitor Structure
Insulin-like Growth Factor-1 Receptor Inhibitor
  • CAS No.468740-43-4
  • Chemical Name:Insulin-like Growth Factor-1 Receptor Inhibitor
  • CBNumber:CB22510062
  • Molecular Formula:C25H26ClN5O3
  • Formula Weight:479.96
  • MOL File:468740-43-4.mol
Insulin-like Growth Factor-1 Receptor Inhibitor Property
  • Melting point >206°C (dec.)
  • Density 1.44
  • storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
  • solubility DMSO (Slightly)
  • pka 10.40±0.10(Predicted)
  • form Solid
  • color Light Yellow to Yellow
  • CAS DataBase Reference 468740-43-4
  • FDA UNII 40E3AZG1MX
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Insulin-like Growth Factor-1 Receptor Inhibitor Chemical Properties,Usage,Production

  • Uses BMS 536924 is an inhibitor of insulin-like growth factor receptor (IGF1R) kinase and insulin receptor. BMS 536924 was reported to have antitumor activity.
  • Definition ChEBI: 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-pyridinone is a member of benzimidazoles.
  • in vivo

    BMS-536924 (100 mg/kg; gavage; daily; for 35 days) causes regression of xenografts in vivo and an average reduction of 76% tumor volume after 2 weeks[2].

    Animal Model:Athymic nude mice with CD8-IGF-IRMCF10A cells[2]
    Dosage:100 mg/kg
    Administration:Gavage; daily; for 35 days
    Result:Caused an average reduction of 76% tumor volume after 2 weeks.
  • storage Store at -20°C
Insulin-like Growth Factor-1 Receptor Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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Insulin-like Growth Factor-1 Receptor Inhibitor Spectrum
468740-43-4, Insulin-like Growth Factor-1 Receptor InhibitorRelated Search:
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 标准品
  • 细胞生物学试剂
  • 蛋白酪氨酸激酶
  • 小分子抑制剂，天然产物
  • C25H26ClN5O3
  • 胰岛素样生长因子-1 受体拮抗剂,10 MM DMSO 溶液
  • (S)-4-((2-(3-氯苯基)-2-羟乙基)氨基)-3-(4-甲基-6-吗啉-1H-苯并[D]咪唑-2-基)吡啶-2(1H)-酮
  • IGF-1R/IR抑制剂(BMS-536924)
  • 胰岛素样生长因子-1 受体拮抗剂
  • 468740-43-4
  • BMS-536924, 10 mM in DMSO
  • Insulin-like Growth Factor-1 Receptor Inhibito
  • BMS-536924 (CS0117
  • (S)-4-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
  • Insulin-like Growth Factor-1 Receptor Inhibitor USP/EP/BP
  • BMS-536924 >=98% (HPLC)
  • 2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-
  • BMS-536924(HY-10262, CS-0117)
  • (S)-4-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one
  • BMS 536924;BMS536924
  • CS-469
  • 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]aMino]-3-[7-Methyl-5-(4-Morpholinyl)-1H-benziMidazol-2-yl]-2(1H)-pyridinone BMS-536924
  • BMS-536924, >=98%
  • BMS-536924 Insulin-like Growth Factor-1 Receptor Inhibitor
  • HY-10262
  • CS-0117
  • 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1H-benzimidazol-2-yl]- 2(1H)-pyridinone
  • Insulin-like Growth Factor-1 Receptor Inhibitor
  • BMS-536924
  • 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone

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