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Creatinine

CAS No.60-27-5
Chemical Name:Creatinine
CBNumber:CB8672212
Molecular Formula:C4H7N3O
Formula Weight:113.12
MOL File:60-27-5.mol

Creatinine Property

Melting point 295 °C (dec.) (lit.)
Boiling point 211.83°C (rough estimate)
Density 1.2526 (rough estimate)
bulk density 484kg/m3
refractive index 1.5700 (estimate)
Flash point 290 °C
storage temp. Sealed in dry,Room Temperature
solubility 1 M HCl: 0.1 g/mL at 20 °C, clear
pka 4.83(at 25℃)
form Crystalline Powder
color White
PH Range 7.5 - 8.5
PH 7.0-9.0 (20°C, 50g/L in H2O)
Water Solubility SOLUBLE
Merck 14,2569
BRN 112061
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey DDRJAANPRJIHGJ-UHFFFAOYSA-N
LogP -1.760
CAS DataBase Reference 60-27-5(CAS DataBase Reference)
EWG's Food Scores 1
NCI Dictionary of Cancer Terms creatinine
FDA UNII AYI8EX34EU
NIST Chemistry Reference Creatinine(60-27-5)
EPA Substance Registry System 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl- (60-27-5)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi,Xn
Risk Statements :34-36/37/38-20/21/22
Safety Statements :26-36/37/39-45-24/25-36
RIDADR :UN 1789 8/PG 3
WGK Germany :3
F :9-23
TSCA :Yes
HS Code :29332990
Toxicity :A degradation product of creatine. Serum creatinine is elevated after eating meat. High serum creatinine may also be indicative of renal failure.

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Creatinine Price More Price(27)

Brand: Sigma-Aldrich(India)
Product number: C4255
Product name : Creatinine
Purity: anhydrous, ≥98%
Packaging: 10MG
Price: ₹779.4
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C4255
Product name : Creatinine
Purity: anhydrous, ≥98%
Packaging: 10G
Price: ₹2089.23
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: C4255
Product name : Creatinine
Purity: anhydrous, ≥98%
Packaging: 25G
Price: ₹3712.98
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: PHR1462
Product name : Creatinine
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1G
Price: ₹8313.6
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C4255
Product name : Creatinine
Purity: anhydrous, ≥98%
Packaging: 100G
Price: ₹10121.38
Updated: 2022/06/14
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Creatinine Chemical Properties,Usage,Production

Description Creatinine is together with urea, the most widely known "uremic toxin", and is usually assessed when- ever a reduction in kidney function is suspected. This is mainly because creatinine evaluation is cheap, widely accessible and relatively well reflects the renal function. It also forms the basis for estimation of estimated glomerular filtration rate (eGFR) and thus is a major component of all principal eGFR equations.
Creatinine, which is nonenzymatically produced from the creatine pool in skeletal muscle, but is also to some extent generated from exogenous creatine present in meat, is the major guanidine compound retained in patients with diminished glomerular filtration rate. Creatinine is routinely determined in plasma or serum as a measure of impairment of renal function and it might be expected that a variety of uremic symptoms correlate with the plasma creatinine level; this does not, however, necessarily imply a causal relationship. In fact, high serum creatinine levels correlate with low mortality in HD patients, presumably because the creatinine generation rate reflects the size of the muscle mass. Creatinine seems to be relatively nontoxic. Large amounts of creatinine have been fed to healthy subjects without any adverse effects and animals also tolerate large doses.
Chemical Properties white powder
Uses Creatinine is the end product of creatine catabolism. Creatinine is a normal constituent of urine. Also found together with creatine in muscle tissues and blood. Creatinine is found in all soils and i n grain seeds and other vegetable matter as well as in certain fish and in crab meat extract.
Uses metabolic enhancer
Uses Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function. It is a substrate for creatininase.
Definition ChEBI: A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.
Biological Functions Creatinine is a byproduct of a chemical compound called creatine, which helps muscles get the energy that they need. As a waste product, creatinine is filtered out of the blood by the kidneys and removed from the body in urine.
A creatinine test measures the amount of this chemical in either the blood or urine. Creatinine levels can provide an indication of how well the kidneys are working.
Creatinine may be measured alone or included in a panel of tests that include other compounds found in the urine or blood.
https://labtestsonline.org/tests/creatinine
https://www.kidney.org/atoz/content/what-creatinine
General Description Creatinine is a breakdown product formed by the degradation of creatine phosphate from muscles. The kidneys extract creatinine from the body by filtering almost all of it from the blood and excreting it in the urine. Serum creatinine is the most commonly used indicator for renal functioning. In chemical synthesis, creatinine is used as a heterocyclic nitrogenous compound that produces electron-rich and highly basic creatinine derivatives.
Purification Methods Likely impurities are creatine and ammonium chloride. Dissolve it in dilute HCl, then neutralise with ammonia. Recrystallise it from H2O by adding excess of Me2CO. The picrate crystallises from 23volumes of boiling H2O and has m 220-221o(dec). [King J Chem Soc 2377 1930, Beilstein 25 III/IV 2543.]