ChemicalBook > CAS DataBase List > 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Structure
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
  • CAS No.1675201-83-8
  • Chemical Name:2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
  • CBNumber:CB23049190
  • Molecular Formula:C29H33NO5
  • Formula Weight:475.58
  • MOL File:1675201-83-8.mol
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Property
  • Boiling point 630.2±55.0 °C(Predicted)
  • Density 1.182±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
  • pka 2.34±0.20(Predicted)
  • form solid
  • color White
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties,Usage,Production

  • Description PD-1/PD-L1 Inhibitor 1 (1675201-83-8) inhibits (IC50 = <100nM) the formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1
  • Uses BMS-1 is a PD-L1 inhibitor which is used in combination with LIF inhibitors for the treatment of cancers.
  • in vitro pd-1/pd-l1 inhibitor 1 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1). pd-1/pd-l1 inhibitor 1 was also found to act as an immunomodulator. in preclinical studies, pd-1/pd-l1 inhibitor 1 was able to block pd-1/pd-ll interactions with an ic50 value between 6 and 100 nm, which was measured by a homogenous time-resolved fluorescence (htrf) binding assay. thus, pd-1/pd-l1 inhibitor 1 might potentially be used for the treatment of cancer as well as infectious diseases, such as hepatitis c [1].
  • in vivo

    BMS-1 (500 μg/mL; 100 μL; i.p.) significantly increases the survival rates of the mVEGF165b group and mVEGF165b + MUC1 group[3].

    Animal Model:BALB/c mice with EMT6 cells[3]
    Dosage:500 μg/mL; 100 μL
    Administration:I.p.
    Result:Increased the survival rates of the mVEGF165b group and mVEGF165b + MUC1 group.
    mVEGF165b combined with MUC1 results significant retardation of the tumor growth.
  • IC 50 0.006-0.10 μm
  • References 1) Chupak?et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials
Raw materials
Preparation Products
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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Spectrum
1675201-83-8, 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-Related Search:
  • 药靶配体
  • 原料药及中间体
  • 抑制剂
  • 其他生化试剂
  • 化合物PD-1/PD-L1 INHIBITOR 1,10 MM DMSO 溶液
  • PD-1/PD-L1抑制剂1,小分子抑制剂
  • PD-1/PD-L1抑制剂杂质8(BMS 1)
  • PD-1 / PD-L1抑制剂1
  • 化合物PD-1/PD-L1 INHIBITOR 1
  • PD-L1 抑制剂1
  • (S)-1-(2,6-二甲氧基-4-((2-甲基-[1,1'-联苯]-3-基)甲氧基)苄基)哌啶-2-甲酸
  • (2S)-1-[[2,6-二甲氧基-4-[(2-甲基[1,1'-联苯]-3-基)甲氧基]苯基]甲基]-2-哌啶羧酸
  • 1675201-83-8
  • BMS-1, 10 mM in DMSO
  • PD-1/PD-L1 inhibitor 1, small molecule inhibitor
  • PD-1/PD-L1 inhibitor Impurity 8 (BMS 1)
  • (S)-1-(2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
  • BMS-1
  • PD-1/PD-L1 inhibitor 1(C1)
  • PD1/PDL1 INHIBITOR 1;PD 1/PD L1 INHIBITOR 1
  • CS-2413
  • BMS-1 (PD-1/PD-L1 inhibitor 1)
  • PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1)
  • (2S)-1-{2,6-Dimethoxy-4-[(2-methyl-3-biphenylyl)methoxy]benzyl}-2-piperidinecarboxylic acid
  • T3655
  • avelumab/PD-L1
  • (2S)-1-[[2,6-Dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid
  • PD-1PD-L1 inhibitor
  • PD1-PDL1 inhibitor 1
  • 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

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