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1675201-83-8

Supplier Related Products Identification Chemical Properties Hazard Information

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Identification

Name
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
CAS
1675201-83-8
Synonyms
T3655
BMS-1
CS-2413
avelumab/PD-L1
PD-1PD-L1 inhibitor
PD1-PDL1 inhibitor 1
PD-1/PD-L1 inhibitor 1(C1)
BMS-1 (PD-1/PD-L1 inhibitor 1)
PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1)
PD1/PDL1 INHIBITOR 1;PD 1/PD L1 INHIBITOR 1
(2S)-1-{2,6-Dimethoxy-4-[(2-methyl-3-biphenylyl)methoxy]benzyl}-2-piperidinecarboxylic acid
(2S)-1-[[2,6-Dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
Molecular Formula
C29H33NO5
MOL File
1675201-83-8.mol
Molecular Weight
475.58

Chemical Properties

Boiling point 
630.2±55.0 °C(Predicted)
density 
1.182±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
pka
2.34±0.20(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Hazard Information

Description
PD-1/PD-L1 Inhibitor 1 (1675201-83-8) inhibits (IC50 = <100nM) the formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1
References
1) Chupak?et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820
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