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1,10-Phenanthroline hydrate

CAS No.5144-89-8
Chemical Name:1,10-Phenanthroline hydrate
CBNumber:CB8290304
Molecular Formula:C12H8N2.H2O
Formula Weight:198.22
MOL File:5144-89-8.mol

1,10-Phenanthroline hydrate Property

Melting point 100-104 °C(lit.)
bulk density 300kg/m3
Density 1.10
vapor density 6.2 (vs air)
storage temp. Sealed in dry,Room Temperature
solubility methanol: soluble200MM (Stock solution is stable for months at –20° C.)
form Needle-Like Crystals
color Off-white, may become cream-colored during storage
biological source synthetic (organic)
Water Solubility <0.01 g/100 mL at 21 ºC
Merck 14,7214
BRN 4008096
Stability Stable. Incompatible with iron, other heavy metals, strong oxidizing agents, strong acids.
CAS DataBase Reference 5144-89-8(CAS DataBase Reference)
FDA UNII KSX215X00E
EPA Substance Registry System 1,10-Phenanthroline, monohydrate (5144-89-8)
UNSPSC Code 51111800
NACRES NA.77

Safety

Hazard Codes :T,N
Risk Statements :25-50/53
Safety Statements :45-60-61
RIDADR :UN 2811 6.1/PG 3
WGK Germany :3
RTECS :SF8437000
TSCA :Yes
HazardClass :6.1
PackingGroup :III
HS Code :29339990
Toxicity :LD50 orally in Rabbit: 132 mg/kg

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H301-H410
Precautionary statements P273-P301+P310+P330

1,10-Phenanthroline hydrate Price More Price(40)

Brand: Sigma-Aldrich(India)
Product number: P9375
Product name : 1,10-Phenanthroline monohydrate
Purity: reagent grade
Packaging: 1G
Price: ₹2608.83
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P9375
Product name : 1,10-Phenanthroline monohydrate
Purity: reagent grade
Packaging: 5G
Price: ₹3604.73
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: P9375
Product name : 1,10-Phenanthroline monohydrate
Purity: reagent grade
Packaging: 25G
Price: ₹10337.88
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P9375
Product name : 1,10-Phenanthroline monohydrate
Purity: reagent grade
Packaging: 100G
Price: ₹30310
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 77500
Product name : 1,10-Phenanthroline monohydrate
Purity: for the spectrophotometric determination of Fe, Pd, V, ≥99.0%
Packaging: 5G
Price: ₹5174.35
Updated: 2022/06/14
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1,10-Phenanthroline hydrate Chemical Properties,Usage,Production

Chemical Properties white crystals or powder
Uses When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.
1,10-Phenanthroline monohydrate is an aromatic nitrogen heterocycle that may be used as a chelating agent in the preparation of metal-chelate complexes.
Uses 1,10-Phenanthroline monohydrate is useful to study the DNA-protein interactions due to its nuclease activity. It is used as a redox indicator and reagent for spectrophotometric assay of silver. It acts as a chelating ligand for the determination of Fe, Pd and V. It also acts as a matrix metalloproteinase inhibitor. It is a photometric reagent for iron, which forms a red chelate with ferrous (iron II) ion.
General Description White crystalline powder or solid. Slight odor.
Air & Water Reactions Insoluble in water.
Reactivity Profile 1,10-Phenanthroline hydrate is incompatible with strong oxidizers. 1,10-Phenanthroline hydrate is also incompatible with strong acids. 1,10-Phenanthroline hydrate forms complex compounds with ferrous ions. .
Fire Hazard Flash point data for 1,10-Phenanthroline hydrate are not available. 1,10-Phenanthroline hydrate is probably combustible.
Biochem/physiol Actions Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.
Purification Methods Crystallise its picrate (m 191o) from EtOH; then the free base is liberated with aqueous alkali, dried at 78o/8mm over P2O5 and crystallised from pet ether (b 80-100o). [Cumper et al. J Chem Soc 1188 1962.] It can be purified by zone melting. It has also been crystallised from hexane, *benzene/pet ether (b 40-60o) or sodium-dried *benzene, dried and stored over H2SO4. The monohydrate is obtained by crystallisation from aqueous EtOH or ethyl acetate. It has been crystallised from H2O (300 parts) to give the monohydrate m 102-103o which sublimes at 10-3mm [Fielding & LeFevre J Chem Soc 1811 1951.] The anhydrous compound has m 118o (after drying at high vacuum at 80o) and is also obtained by recrystallisation from pet ether or *C6H6 (70 parts) and drying at 78o/8mm. [UV: Badger et al. J Chem Soc 3199 1951.] IthasapKainH2Oof 4.857 (25o) or 5.02 (20o) and 4.27 in 50% aqueous EtOH (20o). [Albert et al. J Chem Soc 2240 1948]. [Beilstein 23 H 227, 23 II 235, 23/8 V 419.]