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Neocuproine

CAS No.484-11-7
Chemical Name:Neocuproine
CBNumber:CB0429520
Molecular Formula:C14H12N2
Formula Weight:208.26
MOL File:484-11-7.mol

Neocuproine Property

Melting point 159-164 °C
Boiling point 337.46°C (rough estimate)
Density 1.1345 (rough estimate)
bulk density 280kg/m3
refractive index 1.6152 (estimate)
RTECS SF8380000
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility methanol: 0.1 g/mL, clear
form crystalline
pka 6.01±0.30(Predicted)
color white to beige
Water Solubility slightly soluble
Sensitive Light Sensitive
Merck 6449
InChIKey IYRGXJIJGHOCFS-UHFFFAOYSA-N
CAS DataBase Reference 484-11-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 8E7D2SH3BV
NIST Chemistry Reference 1,10-Phenanthroline, 2,9-dimethyl-(484-11-7)
EPA Substance Registry System 1,10-Phenanthroline, 2,9-dimethyl- (484-11-7)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi,Xn
Risk Statements :36/37/38-20/21/22-22
Safety Statements :26-36/37/39-36-24/25
WGK Germany :3
TSCA :Yes
HS Code :29339990

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Neocuproine Price More Price(15)

Brand: Sigma-Aldrich(India)
Product number: N1501
Product name : Neocuproine
Purity: ≥98%
Packaging: 1G
Price: ₹4286.7
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: N1501
Product name : Neocuproine
Purity: ≥98%
Packaging: 5G
Price: ₹13076.6
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: N1501
Product name : Neocuproine
Purity: ≥98%
Packaging: 25G
Price: ₹26337.23
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 1.02968
Product name : Neocuproine
Purity: GR for analysis
Packaging: 5G
Price: ₹22250
Updated: 2022/06/14
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Brand: ottokemi
Product number: N 1377
Product name : Neocuproine
Purity: , GR 99%+
Packaging: 1gm
Price: ₹1341
Updated: 2022/05/26
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Neocuproine Chemical Properties,Usage,Production

Chemical Properties Neocuproine is a off-white to very pale yellow crystalline powder, in the presence of reducing agents it reacts with copper to give a copper(I) complex of composition MA2 and of tetrahedral symmetry.
Uses Neocuproine is a phenanthroline based metal ion chelating agent.
Uses Due to the steric hindrance of the methyl groups attached to the carbon atoms adjacent to the nitrogen donor atoms of phenanthroline, the reagent does not give the low spin vivid red complex characteristic of phenanthroline derivatives with iron(II). However, in the presence of reducing agents it reacts with copper to give a copper(I) complex of composition MA2 and of tetrahedral symmetry. This chelate is insoluble in water and can be extracted by chloroform in which the absorption maximum of the complex appears at 457 nm. In this way the concentration of the complex can be measured. The method is suitable for the determination of copper in iron, manganese and vanadium ores even in the presence of aluminium, germanium, titanium and silicon.
Neocuproine is today considered one of the most selective reagents. Unfortunately, it is rather expensive. 2,3-bis-(2-pyridyl)quinoxaline, prepared by Belcher et al. by condensation of o-diketone, 2,2'-dipyridyl and 0-phenylenediamine(44) contains the functional grouping characteristic of cuproine; it is quite suitable for the determination of copper and it is cheap. Starting with various substituted o-phenylene-diamines Belcher synthesized 25 different quinoxaline derivatives, of which 2,3-bis-[2-(-methyl)-pyridyl)]quinoxaline proved to be identical with neocuproine as regards analytical selectivity. Besides copper, titanium(III) is the only metal ion which gives a colour reaction with the reagent. However, the coloured titanium(III) complex is formed only at lower pH and hence it does not interfere with the determination of copper. The copper complex of the reagent can be extracted quantitatively with isopentyl alcohol usually as a perchlorate ion pair.
Definition ChEBI: A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9.
Purification Methods Purifiy it as the hemihydrate by crystallisation from water and as the anhydrous base from *benzene. [Beilstein 23/8 V 527.]