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1-Fluoronaphthalene

CAS No.321-38-0
Chemical Name:1-Fluoronaphthalene
CBNumber:CB8219439
Molecular Formula:C10H7F
Formula Weight:146.16
MOL File:321-38-0.mol

1-Fluoronaphthalene Property

Melting point -13 °C (lit.)
Boiling point 215 °C (lit.)
Density 1.1322 g/mL at 20 °C (lit.)
refractive index n20/D 1.593(lit.)
Flash point 150 °F
storage temp. Sealed in dry,Room Temperature
solubility slightly soluble in water, well soluble in chloroform, ethyl acetate, and methanol.
form Oil
color Colourless to Yellow
Specific Gravity 1.332
Water Solubility Not miscible or difficult to mix in water.
BRN 1906413
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey CWLKTJOTWITYSI-UHFFFAOYSA-N
CAS DataBase Reference 321-38-0(CAS DataBase Reference)
FDA UNII 0920702UT7
NIST Chemistry Reference Naphthalene, 1-fluoro-(321-38-0)
EPA Substance Registry System 1-Fluoronaphthalene (321-38-0)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36
RIDADR :UN2810
WGK Germany :3
RTECS :QJ7100000
Hazard Note :Flammable
TSCA :T
HazardClass :IRRITANT
HS Code :29039990

NFPA 704:

	2
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338

1-Fluoronaphthalene Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: 196657
Product name : 1-Fluoronaphthalene
Purity: 99%
Packaging: 5G
Price: ₹2574.2
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 196657
Product name : 1-Fluoronaphthalene
Purity: 99%
Packaging: 25G
Price: ₹9442.25
Updated: 2022/06/14
Buy: Buy

Brand: ALFA India
Product number: ALF-A18378-22
Product name : 1-Fluoronaphthalene, 98%
Purity:
Packaging: 100g
Price: ₹29155
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: F0212
Product name : 1-Fluoronaphthalene
Purity: min. 98.0 %
Packaging: 5G
Price: ₹2700
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: F0212
Product name : 1-Fluoronaphthalene
Purity: min. 98.0 %
Packaging: 25G
Price: ₹6900
Updated: 2022/05/26
Buy: Buy

1-Fluoronaphthalene Chemical Properties,Usage,Production

Chemical Properties clear slightly yellow to yellow-brown liquid
Uses 1-Fluoronaphthalene is a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. It is also used as a pharmaceutical intermediate. It is Duloxetine impurity.
Application 1-Fluoronaphthalene was used in t-BuLi-mediated synthesis of 6-substituted phenanthridines. It was also used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake.
Preparation The preparation of 1-Fluoronaphthalene is as follows:1) Diazotization reaction: 1500 g of hydrochloric acid (mass concentration: 25%) and 300 g of naphthylamine were added to a 3000 mL three-necked flask, stirred and heated to 75 ° C to dissolve, and the temperature was lowered to below 5 ° C, and 148 g was slowly added at this temperature. Sodium nitrite, stirred at low temperature for 0.3 hours after the addition, to obtain a diazonium salt solution;2) Substitution reaction: 360 g of fluoroboric acid solution (concentration: 45%) was added to the resulting solution obtained in the step 1), stirred for 0.25 h, filtered, and the filter cake was dried at a temperature of 50 ° C for 0.2 h to obtain Dry naphthylamine diazonium salt fluoroborate double salt;3) Hot air decomposition: the dried diazonium salt fluoroborate double salt is slowly added to the reactor through which hot air (hot air temperature is 85-90 ° C), and the dried powdered naphthylamine diazonium salt fluoroborate double salt is The hot air blows up the dispersion and absorbs the heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities;4) Purification treatment: the 1-fluoronaphthalene solution obtained in the step 3) is first washed with pure water for 3 to 6 times, then neutralized with a soda ash to a pH of 6.8 to 7.2, and finally the oil layer is separated by filtration, and the filtrate is taken. The distillation treatment gave 210 g of a naphthalene-based fluorine-containing intermediate 1-fluoronaphthalene in an amount of 99.8%.
Air & Water Reactions Insoluble in water.
Reactivity Profile Simple aromatic halogenated organic compounds, such as Fluoronaphthalene, are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.