1-Bromo-4-fluoronaphthalene

Chemical Properties

Uses

Synthesis

321-38-0

341-41-3

General procedure for the synthesis of 1-bromo-4-fluoronaphthalene from 1-fluoronaphthalene: 1-fluoronaphthalene (20.0 g, 0.137 mol) was added to a 500 mL single-necked flask with carbon tetrachloride (120.0 mL), and bromine (10.9 g, 0.068 mol) was added dropwise slowly, followed by heating and refluxing for 2 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure and then the concentrate was poured into methanol (80.0 mL). The solid was allowed to precipitate overnight at room temperature to give 28.2 g of 1-bromo-4-fluoronaphthalene in 91.5% yield.

References