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ADRENORPHIN

ADRENORPHIN Structure
ADRENORPHIN
  • CAS No.88377-68-8
  • Chemical Name:ADRENORPHIN
  • CBNumber:CB8129589
  • Molecular Formula:C44H69N15O9S
  • Formula Weight:984.18
  • MOL File:88377-68-8.mol
ADRENORPHIN Property
  • Density 1.42±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO
  • form Solid
  • pka 9.97±0.15(Predicted)
  • color White to off-white
  • Sequence H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

ADRENORPHIN Chemical Properties,Usage,Production

  • Uses Adrenorphin is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with Ki of 12 nM.
  • Biological Activity adrenorphin (metorphamide) is a potent inhibitor of nicotine-induced adrenaline and noradrenaline release with ic50 value of 10 μm [1].adrenorphin (metorphamide) is an endogenous, c-terminally amidated, opioid octapeptide (tyr-gly-gly-phe-met-arg-arg-val-nh2) that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain [2].adrenorphin (metorphamide) is selective nicotine-induced adrenaline and noradrenaline release inhibitor and has higher than 100-fold more potent than the reported nicotine-induced adrenaline and noradrenaline release inhibitor met5-enkephalin. when tested with bovine adrenal chromaffin cells, adrenorphin (metorphamide) showed inhibition on 5 μm nicotine-induced atp release by almost 50% at 5μm and the inhibition was not in a dose-dependent manner [1]. in bioassays and binding assays, metorphamide exhibited high μ-binding activity, as well as κ-binding activity with nearly half percent toμ-binding activity, while showed no activity on δ-binding [2].
  • IC 50 μ Opioid Receptor/MOR
  • References [1]. marley, p.d., k.i. mitchelhill, and b.g. livett, metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. brain res, 1986. 363(1): p. 10-7.
    [2]. weber, e., et al., metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. proc natl acad sci u s a, 1983. 80(23): p. 7362-6.
ADRENORPHIN Preparation Products And Raw materials
Raw materials
Preparation Products
ADRENORPHIN Suppliers
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ADRENORPHIN Spectrum
88377-68-8, ADRENORPHINRelated Search:
  • CancerBiology
  • Peptide
  • 抑制剂
  • 目录肽
  • 多肽
  • 目录多肽
  • 标准品
  • C44H69N15O9S1
  • C44H69N15O9S
  • 受体激动剂多肽METORPHAMIDE
  • YV-8-NH2
  • 化合物ADRENORPHIN(3TFA)
  • 88377-68-8
  • Adrenorphin 3TFA(88377688(free base)),Adrenorphin 3TFA(88377 68 8(free base))
  • Adrenorphin 3TFA(88377-68-8(free base))
  • Adrenorphin (human)
  • L-Valinamide, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-
  • Adrenorphin(3TFA)
  • Adrenorphin (metorphamide)
  • Tyr-Gly-Gly-Phe-Arg-Arg-Val-NH2
  • Metorphamide, Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val amide
  • adrenorphin amide
  • TYROSINE-GLYCINE-GLYCINE-PHENYLALANINE-METHIONINE-ARGININE- ARGININE-VALINE AMIDE)
  • tyr-gly-gly-phe-met-arg-arg-val amide
  • PROENKEPHALIN (206-213) (BOVINE)
  • TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2
  • ADRENORPHIN (BOVINE)
  • ADRENORPHIN
  • METORPHAMIDE
  • METORPHINAMIDE
  • METORPHIN
  • H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2

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