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BAM-22P

BAM-22P Structure
BAM-22P
  • CAS No.76622-26-9
  • Chemical Name:BAM-22P
  • CBNumber:CB0345600
  • Molecular Formula:C130H184N38O31S2
  • Formula Weight:2839.22
  • MOL File:76622-26-9.mol
BAM-22P Property
  • Density 1.50±0.1 g/cm3(Predicted)
  • RTECS SC6200500
  • storage temp. -15°C
  • solubility Soluble to 1 mg/ml in H2O
  • form Lyophilized solid
  • Water Solubility Soluble to 1 mg/ml in water
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

BAM-22P Chemical Properties,Usage,Production

  • Uses BAM-22P, a highly potent opioid peptide, is a potent opioid agonist.
  • Biological Activity bovine adrenal medulla 22 peptide (bam22p) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin a, the precursor of leu- and met-enkephalin, in the adrenal medulla, with very potent opiate activity.
  • in vitro in the guinea-pig ileum assay, bam-22p has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. the potency of bam-22p is 26 times that of met-enkephalin and 22 times that of b hendorphin. ic50 value of bam-22p in this tissue, 1.3 nm, makes it the most potent met-enkephalin relatives that discoveried so far. [1].
  • in vivo intrathecal (i.t.) administration of bam22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. such decrease was partially attenuated by systemic injection of naloxone. [2].
  • target

    Opioid receptor

  • IC 50 1.3 nm for opiate activity
  • References [1] mizuno k, minamino n, kangawa k, matsuo h. a new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (bam-22p) and eicosapeptide (bam-20p) with very potent opiate activity. biochem biophys res commun. 1980 dec 31;97(4):1283-90.
    [2] hong y, dai p, jiang j, zeng x. dual effects of intrathecal bam22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. br j pharmacol. 2004 feb;141(3):423-30.
BAM-22P Preparation Products And Raw materials
Raw materials
Preparation Products
BAM-22P Suppliers
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BAM-22P Spectrum
76622-26-9, BAM-22PRelated Search:
  • Various Peptides
  • Peptide
  • 抑制剂
  • 多肽
  • 目录肽
  • C130H184N38O31S2
  • 化合物BAM 22P ACETATE
  • 阿片肽BAM-22P
  • 76622-26-9
  • BAM 22P acetate
  • Glycine, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-α-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-
  • BAM-22P H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH
  • H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-TRP-TRP-MET-ASP-TYR-GLN-LYS-ARG-TYR-GLY-OH
  • BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE
  • BOVINE ADRENAL MEDULLA-22P
  • BAM-22P
  • AP1B1
  • AP105A
  • ADTB1
  • Peptide E(1-22)
  • L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Arg-L-Val-Gly-L-Arg-L-Pro-L-Glu-L-Trp-L-Trp-L-Met-L-Asp-L-Tyr-L-Gln-L-Lys-L-Arg-L-Tyr-Gly-OH
  • BAM22
  • YGGFMRRVGRPEWWMDYQKRYG
  • TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-TRP-TRP-MET-ASP-TYR-GLN-LYS-ARG-TYR-GLY

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