Met-enkephalin-Arg-Phe
- Product NameMet-enkephalin-Arg-Phe
- CAS73024-95-0
- CBNumberCB8736282
- MFC42H56N10O9S
- MW877.02
- EINECS-0
- MDL NumberMFCD00076425
- MOL File73024-95-0.mol
Chemical Properties
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | -15°C |
| pka | 3.49±0.10(Predicted) |
| Sequence | Tyr-Gly-Gly-Phe-Met-Arg-Phe |
Met-enkephalin-Arg-Phe Chemical Properties,Usage,Production
Uses
Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity[1].Definition
ChEBI: Met-enkephalin-Arg-Phe is an organic molecular entity.in vivo
Met-Enkephalin-Arg-Phe (10-100 nmol/mouse; i.c.v.; once) shows analgesic activity in mice[1].
| Animal Model: | Male Swiss Webster mice[1] |
| Dosage: | 10-100 nmol/mouse |
| Administration: | Intracerebralventricular injection, once |
| Result: | Produced a dose-related inhibition of the tail-flick response. The effects peaked at 2-4 min and were dissipated by 10 min. The EC50 was 38.5 nmol/mouse. |
References
[1] Inturrisi CE, et al. Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5512-4. DOI:10.1073/pnas.77.9.5512Met-enkephalin-Arg-Phe Supplier
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