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Zorubicin

Zorubicin Structure
Zorubicin
  • CAS No.54083-22-6
  • Chemical Name:Zorubicin
  • CBNumber:CB7875401
  • Molecular Formula:C34H35N3O10
  • Formula Weight:645.66
  • MOL File:54083-22-6.mol
Zorubicin Property
  • Boiling point 675.08°C (rough estimate)
  • Density 1.2920 (rough estimate)
  • refractive index 1.7800 (estimate)
  • FDA UNII V25F9362OP
  • ATC code L01DB05
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Zorubicin Chemical Properties,Usage,Production

  • Originator Zorubicin Hydrochloride,ZYF Pharm Chemical
  • Uses Antineoplastic.
  • Manufacturing Process 9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).
  • Therapeutic Function Antineoplastic, Antileukemic
  • in vivo

    Zorubicin (12-18 mg/kg; i.p. 48 h after tumour cells injection) affects leukaemic colony forming units[1]. Zorubicin (0.75-6.0 mg/kg; i.v.) increases plasma histamine concentrations and produces immediate hypotension in anesthetized beagle dogs[3].

    Animal Model:Six- to eight-week-old male DBA2 mice with P388 tumour cells[1]
    Dosage:12-18 mg/kg
    Administration:Intraperitoneal injection ; 12-18 mg/kg; 48 h after tumour cells injection
    Result:Showed a D1/2 value of 1.6 mg/kg for leukaemic colony forming units.
Zorubicin Preparation Products And Raw materials
Raw materials
Preparation Products
Zorubicin Suppliers
Global(11)Suppliers
  • Supplier： TargetMol Chemicals Inc.
  • Tel： 15002134094
  • Email：marketing@targetmol.cn
  • Country：China
  • ProdList：19725
  • Advantage：58
Zorubicin Spectrum
54083-22-6, ZorubicinRelated Search:
  • 抑制剂
  • C34H35N3O10
  • 化合物 ZORUBICIN
  • RUBIDAZON ; RUBIDAZONE|||RUBIDAZONE|||RUBIDAZON
  • 佐柔比星
  • 正定苯酰肼
  • 54083-22-6
  • Rubidazone|||Rubidazone|||Rubidazon
  • Benzoic acid, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide
  • N-[(E)-1-[(2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide
  • Zorubicin [inn]
  • Ccris 2260
  • Brn 1417621
  • Benzoylhydrazone daunorubicin
  • Benzoic acid, (1-(4-((3-amino-2,3,6-trideoxy-alpha,L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide, (2S-cis)-
  • RUBIDAZON
  • Benzoic acid, 1-(2S,4S)-4-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenylethylidenehydrazide
  • ZORUBICIN
  • Rubidazone
  • Daunomycin benzoylhydrazone
  • Benzoic acid 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxonaphthacen-2-yl]ethylidene] hydrazide
  • N-[1-[(2S,4S)-4-(4-Amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide

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