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ZORUBICIN HCL

ZORUBICIN HCL Structure
ZORUBICIN HCL
  • CAS No.36508-71-1
  • Chemical Name:ZORUBICIN HCL
  • CBNumber:CB3339363
  • Molecular Formula:C34H36ClN3O10
  • Formula Weight:682.12
  • MOL File:36508-71-1.mol
ZORUBICIN HCL Property
  • alpha D20 -50° (c = 0.2 in water)
  • solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
  • form Solid
  • color Orange to Dark Red
  • Stability Light Sensitive
  • FDA UNII WXM8D9M6DE
Safety
  • Toxicity :LD50 in mice (mg/kg): 13.66 s.c., 4.42 i.p., 8.50 i.v. (Maral, 1972)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

ZORUBICIN HCL Chemical Properties,Usage,Production

  • Originator Zorubicin Hydrochloride,ZYF Pharm Chemical
  • Uses Antineoplastic.
  • Uses Zorubicin Hydrochloride is an anthracycline anti-cancer drug related to Daunorubicin (D194500).
  • Manufacturing Process 9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).
  • Therapeutic Function Antineoplastic, Antileukemic
ZORUBICIN HCL Preparation Products And Raw materials
Raw materials
Preparation Products
ZORUBICIN HCL Suppliers
Global(29)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20235
  • Advantage：58
  • Supplier： LGM Pharma
  • Tel：1-(800)-881-8210
  • Email：inquiries@lgmpharma.com
  • Country：United States
  • ProdList：2123
  • Advantage：70
  • Supplier： ChemStrong Scientific Co.,Ltd
  • Tel：0755-0755-66853366<br/>13670046396
  • Email：sales@chem-strong.com
  • Country：China
  • ProdList：18131
  • Advantage：56
  • Supplier： Energy Chemical
  • Tel：021-58432009<br/>400-005-6266
  • Email：marketing@energy-chemical.com
  • Country：China
  • ProdList：44918
  • Advantage：58
ZORUBICIN HCL Spectrum
36508-71-1, ZORUBICIN HCLRelated Search:
  • 药物
  • 其它抗生素
  • 抗生素
  • C34H35N3O10HCl
  • 盐酸唑比星
  • 盐酸佐鲁比星杂质
  • (2S-CIS)-苯甲酸[1-[4-[(3-氨基-2,3,6-三脱氧-Α-L-来苏糖-己吡喃基)氧]-1,2,3,4,6,11-六氢-2,5,12-三羟基-7-甲氧基-6,11-二氧-2-萘基]亚乙基]腙盐酸盐
  • 36508-71-1
  • ZORUBICIN HCL USP/EP/BP
  • Benzoic acid, [1-[4-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, monohydrochloride, (2S-cis)-
  • (2S-cis)-Benzoic acid[1-[4-[(3-amino-2，3，6-trideoxy-α-L-lyxo-hex-opyranosyl)oxy]-1，2，3，4，6，11-hexahydro-2，5，12-trihydroxy-7-methoxy-6，11-dioxo-2-napthacenyl]ethylidene]hydrazide hydroehloride
  • Benzoic acid, 1-(2S,4S)-4-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenylethylidenehydrazide, monohydrochloride
  • rubidazone,monohydrochloride
  • rubidaz
  • rp22,050hydrochloride
  • nsc-164011
  • daunorubicin,benzoylhydrazone,monohydrochloride
  • benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride
  • 22050r.p.
  • ZORUBICIN HCL

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