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CHROMANOL 293B

CHROMANOL 293B Structure
CHROMANOL 293B
  • CAS No.163163-23-3
  • Chemical Name:CHROMANOL 293B
  • CBNumber:CB7710010
  • Molecular Formula:C15H20N2O4S
  • Formula Weight:324.4
  • MOL File:163163-23-3.mol
CHROMANOL 293B Property
  • Boiling point 474.1±55.0 °C(Predicted)
  • Density 1.33±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO: 18 mg/mL
  • pka 12.96±0.60(Predicted)
  • form solid
  • color white
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H312-H332
  • Precautionary statements P280
CHROMANOL 293B Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: C2615
  • Product name : Chromanol 293B
  • Purity: ≥98% (HPLC), powder
  • Packaging: 10MG
  • Price: ₹20827.3
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C2615
  • Product name : Chromanol 293B
  • Purity: ≥98% (HPLC), powder
  • Packaging: 50MG
  • Price: ₹91860.95
  • Updated: 2022/06/14
  • Buy: Buy

CHROMANOL 293B Chemical Properties,Usage,Production

  • Description Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR.
  • Uses Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.
  • Definition ChEBI: Chromanol 293B is a 1-benzopyran.
  • General Description Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).
  • Biological Activity Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M).
  • Biochem/physiol Actions Blocker of the slow delayed rectifier K+ current via KCNQ1 channels
  • storage Room temperature
CHROMANOL 293B Preparation Products And Raw materials
Raw materials
Preparation Products
CHROMANOL 293B Suppliers
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CHROMANOL 293B Spectrum
163163-23-3, CHROMANOL 293BRelated Search:
  • Potassium channel
  • 抑制剂
  • 化合物 CHROMANOL 293B
  • 化合物 T22662
  • 二乙酰醇293B
  • 163163-23-3
  • Chromanol 293B >=98% (HPLC), powder
  • Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-
  • Chromagnol
  • N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide
  • 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane
  • CHROMANOL 293B
  • TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE

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