163163-23-3

Chromanol 293B is a blocker of slowly activating delayed-rectifier K⁺ current (I_Ks) with an IC₅₀ value of 6.89 μM in Xenopus oocytes expressing rat I_Ks channels. It is selective, having no activity at rat K_v1.1 or K_ir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of I_Ks in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl^- currents (I_CTFR) with an IC₅₀ value of 19 μM in Xenopus oocytes expressing human CTFR.

Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

ChEBI: Chromanol 293B is a 1-benzopyran.

Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).

Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M).

Blocker of the slow delayed rectifier K+ current via KCNQ1 channels

Room temperature