Uses
(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K+ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic[1].
Definition
ChEBI: Chromanol 293B is a 1-benzopyran.
Biological Activity
Enantiomer that selectively inhibits the slow component of delayed rectifier K + current (I Ks ). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC 50 values are 1.36 and 9.6 μ M respectively). Has negligible inhibitory action at hERG channels (IC 50 > 30 μ M).
References
[1] Yang IC, et al. Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J Pharmacol Exp Ther. 2000;294(3):955-962. PMID:10945846
![(-)-[3R,4s]-chromanol 293b Structure](https://www.chemicalbook.com/CAS/GIF/163163-24-4.gif)