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L-M-TYROSINE

CAS No.587-33-7
Chemical Name:L-M-TYROSINE
CBNumber:CB7374959
Molecular Formula:C9H11NO3
Formula Weight:181.19
MOL File:587-33-7.mol

L-M-TYROSINE Property

Melting point 260-270°C
alpha D22 -14.5° (70% ethanol); D22 +8.9° (70% ethanol, 2N HCl)
Boiling point 387.2±32.0 °C(Predicted)
Density 1.333±0.06 g/cm3(Predicted)
storage temp. Store at RT.
solubility Soluble in dimethyl sulfoxide, dilute acid.
pka 2.20±0.10(Predicted)
form Solid
color White to Pale Beige
Water Solubility 2mg/mL, clear (0.1N HCl)
CAS DataBase Reference 587-33-7(CAS DataBase Reference)
FDA UNII D5YF57V4QW
UNSPSC Code 12352200
NACRES NA.77

Safety

Risk Statements :36/37/38
Safety Statements :26-36/37/39
HS Code :2922500090

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319-H315
Precautionary statements P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

L-M-TYROSINE Chemical Properties,Usage,Production

Chemical Properties Pale Beige Solid
Uses It is an unnatural amino acid ; shown application in the treatment of Parkinson disease, Alzheimer disease, artritis
Uses An unnatural amino acid, that has demonstrated potential in treating Parkinsons disease, Alzheimers disease, and arthritis.
Uses It is an unnatural amino acid ; shown application in the treatment of Parkinson’s disease, Alzheimer’s disease, artritis.
Definition ChEBI: L-m-tyrosine is a hydroxyphenylalanine that is L-phenylalanine with a substituent hydroxy group at position 3. It has a role as a plant metabolite. It is a hydroxyphenylalanine, a L-phenylalanine derivative, a non-proteinogenic L-alpha-amino acid and a member of phenols. It is a tautomer of a L-m-tyrosine zwitterion.
Biological Activity L-Meta-tyrosine is metabolite of L-Phenylalanine generated within the living organism by hydroxyl free radical. It is a marker of oxidative stress. Circulating L-Meta-tyrosine cold be incorporated into protein through the binding to the tRNAPhe. In plants L-Meta-tyrosine (m-Tyr) is also synthesized enzymatically and has been shown to act as a natural herbicide. It inhibits the growth of plants. L-Meta-tyrosine is a potent and selective competitive inhibitor of Enterobacteriaceae (Citrobacter, Proteus, Erwinia) tyrosine phenol-lyase th at exhibits a renoprotective effect in diabetic mice. L-Meta-tyrosine decreases plasma phenyl sulfate and indoxyl sulfate levels and reduces albuminuria in diabetic mice models. Also, L-Meta-tyrosine inhibits bacterial tryptophan indole-lyase. It does not alter composition of microbiota in renal failure mice model.
in vivo
L-m-tyrosine (150 mg/kg; i.p.; single injection) reduces dopamine, norepinephrine and serotonin levels in the brain to approximately 50% of control values (at 60-90 min after injection) in male Sprague-Dawley rats^[3].