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DROXIDOPA

DROXIDOPA Structure
DROXIDOPA
  • CAS No.23651-95-8
  • Chemical Name:DROXIDOPA
  • CBNumber:CB1699324
  • Molecular Formula:C9H11NO5
  • Formula Weight:213.19
  • MOL File:23651-95-8.mol
DROXIDOPA Property
  • Melting point 232-235° (dec); mp 229-232° (dec) (Ohashi)
  • alpha D20 -39° (c = 1 in 1N aq HCl); D20 -42.0° (c = 1 in 1N aq HCl)
  • Boiling point 549.8±50.0 °C(Predicted)
  • Density 1.608±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO: ≥3mg/mL
  • pka 2.09±0.24(Predicted)
  • form powder
  • color white to tan
  • Merck 14,3457
  • Stability Hygroscopic
  • CAS DataBase Reference 23651-95-8
  • FDA UNII J7A92W69L7
  • ATC code C01CA27
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26
  • WGK Germany  :3
  • RTECS  :VT9626010
  • HS Code  :29225090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
DROXIDOPA Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: D9446
  • Product name : L-DOPS
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹14451.38
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D9446
  • Product name : L-DOPS
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹58390.05
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4235
  • Product name : Droxidopa
  • Purity: 
  • Packaging: 50MG
  • Price: ₹8000
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4235
  • Product name : Droxidopa
  • Purity: 
  • Packaging: 200MG
  • Price: ₹24000
  • Updated: 2022/05/26
  • Buy: Buy

DROXIDOPA Chemical Properties,Usage,Production

  • Description Droxidopa is a synthetic amino acid precursor of (-)-norepinephrine which is absorbed from the gut and metabolized to norepinephrine. In Parkinsonian patients, droxidopa added to existing levodopa/decarboxylase inhibitor therapy produces significant improvements in retropulsion, dysarthria and muscular rigidity refractory to other treatments; however, tremor was unaffected.
  • Description Droxidopa (L-DOPS) is a synthetic precursor and prodrug of the neurotransmitter norepinephrine. It is transformed into norepinephrine through the action of DOPA decarboxylase. L-DOPS increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 μg/animal, respectively. It increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg. L-DOPS crosses the blood brain barrier, however, its effects can be blocked by the peripherally-restricted DOPA decarboxylase inhibitor carbidopa , indicating that the mechanism is peripheral. Formulations containing droxidopa are used in the treatment of neurogenic orthostatic hypotension.
  • Chemical Properties Off-White Solid
  • Originator Sumitomo (Japan)
  • Uses Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
  • Uses The L-threo-form Droxidopa. A synthetic amino acid precursor of Norepinephrine (N674500). Antiparkinsonian.
  • Uses L-DOPS has been administered for clinical trial studies in mice with amyloid pathology.
  • Definition ChEBI: A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension
  • brand name DOPS
  • General Description L-DOPS, also called L-threo 3,4-Dihydroxyphenylserine or droxidopa is a catecholamine. L-DOPS has many clinical advantages and may be useful for treating norepinephrine deficiency. It is used for treating neurogenic orthostatic hypotension and improves norepinephrine levels. L-DOPS mediates reduction of amyloid plaques and could have a therapeutic potential for treating amyloid pathology.
  • Biochem/physiol Actions L-DOPS is a norepinephrine precursor in vivo.
DROXIDOPA Preparation Products And Raw materials
Raw materials
Preparation Products
DROXIDOPA Suppliers
Global(286)Suppliers
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DROXIDOPA Spectrum
23651-95-8, DROXIDOPARelated Search:
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  • 原料药
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • C9H11NO5
  • 屈昔多巴,10 MM DMSO 溶液
  • 屈昔多巴杂质A
  • 屈西多巴/屈昔多巴/
  • 右旋多巴
  • (-)-(2S,3R)-2-氨基-3-羟基-3-(3,4-二羟基苯基)丙酸
  • 屈昔多巴杂质B
  • 屈昔多巴杂质
  • 屈昔多巴
  • 屈西多巴
  • 23651-95-8
  • Droxidopa, 10 mM in DMSO
  • Droxidopa Reference Standard
  • roxidopa
  • L-threo-3,4-Dihydroxyphenylserine
  • Droxidopa (JAN)
  • DroxidopaQ: What is Droxidopa Q: What is the CAS Number of Droxidopa Q: What is the storage condition of Droxidopa Q: What are the applications of Droxidopa
  • (2S,3R)-2-azaniumyl-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate
  • L-3,4-Dihydroxyphenylserine
  • L-3,4-Dihydroxyphenylserine trifluoroacetate salt
  • DROXIDOPA USP/EP/BP
  • Droxidopa&gt
  • Droxidopa impurity A
  • Droxidopa (L-DOPS,SM-5688)
  • SM5688; DROXIDOPA (L DOPS;SM 5688)
  • Droxidopa (L DOPS
  • l-threodops
  • l-threo-3-(3,4-dihydroxyphenyl)serine
  • l-dops
  • 4-dihydroxyphenyl)-3-(l-threo-serin
  • 3-dihydroxy-betthreo-l-tyrosin
  • 3-dihydroxy-bet(beta-r)-l-tyrosin
  • (-)-(2s,3r)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionicacid
  • Droxidopa impurity B
  • (2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid
  • L-Tyrosine, b,3-dihydroxy-, (bR)-
  • DROXIDOPA,SM 5688
  • (2S,3R)-2-aMino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid

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