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Promazine hydrochloride

Promazine hydrochloride Structure
Promazine hydrochloride
  • CAS No.53-60-1
  • Chemical Name:Promazine hydrochloride
  • CBNumber:CB7359640
  • Molecular Formula:C17H21ClN2S
  • Formula Weight:320.88
  • MOL File:53-60-1.mol
Promazine hydrochloride Property
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22-43
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :SO8575000
  • HS Code  :2934302300
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H317
  • Precautionary statements P280-P301+P312+P330
Promazine hydrochloride Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: P6656
  • Product name : Promazine hydrochloride
  • Purity: 
  • Packaging: 25G
  • Price: ₹11009.03
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 46674
  • Product name : Promazine hydrochloride
  • Purity: VETRANAL?, analytical standard
  • Packaging: 250MG
  • Price: ₹5066.1
  • Updated: 2022/06/14
  • Buy: Buy

Promazine hydrochloride Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Uses Promazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells.
  • Uses Antipsychotic. Tranquilizer.
  • Definition Isomeric with promethazine hydrochloride.
  • brand name Sparine (Baxter Healthcare); Sparine (Wyeth).
  • General Description Promazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.
  • Biochem/physiol Actions D2 dopamine receptor antagonist; phenothiazine antipsychotic.
  • Clinical Use Antipsychotic for agitation and restlessness
  • Safety Profile Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, tremors, antipsychotic effects. An addltive permitted in food for human consumption; also permitted in the feed and drinhng water of animals and/or for the treatment of food-producing animals. When heated to decomposition it emits toxic fumes of NOx, SOx, and HCl
  • Drug interactions Potentially hazardous interactions with other drugs
    Anaesthetics: enhanced hypotensive effect.
    Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone.
    Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone.
    Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
    Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
    Antiepileptics: antagonised (convulsive threshold lowered).
    Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
    Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
    Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
    Anxiolytics and hypnotics: increased sedative effects.
    Atomoxetine: increased risk of ventricular arrhythmias.
    Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
    Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
    Desferrioxamine: avoid concomitant use.
    Diuretics: enhanced hypotensive effect.
    Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
    Pentamidine: increased risk of ventricular arrhythmias.
    Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval - avoid with amiodarone, disopyramide and dronedarone.
    Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
    Antidepressants: increased level of tricyclics (possibly increased risk of ventricular arrhythmias and antimuscarinic side effects); increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
    Anticonvulsant: antagonises anticonvulsant effect.
    Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
    Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
    Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
    Anxiolytics and hypnotics: increased sedative effects.
    Atomoxetine: increased risk of ventricular arrhythmias.
    Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
    Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
    Diuretics: enhanced hypotensive effect.
    Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
    Pentamidine: increased risk of ventricular arrhythmias.
  • Metabolism Promazine undergoes considerable first-pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and faeces in the form of numerous active and inactive metabolites.
Promazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Promazine hydrochloride Suppliers
Global(128)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
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    SIMAGCHEM CORP
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    TargetMol Chemicals Inc.
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  • Supplier：
    AFINE CHEMICALS LIMITED
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  • Email：sales@afinechem.com
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Promazine hydrochloride Spectrum
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