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BML-275

BML-275 Structure
BML-275
  • CAS No.1219168-18-9
  • Chemical Name:BML-275
  • CBNumber:CB72614842
  • Molecular Formula:C24H27Cl2N5O
  • Formula Weight:472.41008
  • MOL File:1219168-18-9.mol
BML-275 Property
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility insoluble in EtOH; insoluble in H2O; ≥11.34 mg/mL in 0.9% NS ; ≥39.93 mg/mL in DMSO:H2O=2:1 ; ≥5.91 mg/mL in DMSO
  • form Light yellow powder solid.
  • color Yellow
  • Stability Hygroscopic
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

BML-275 Chemical Properties,Usage,Production

  • Description Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.
  • Uses Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
  • in vivo

    Dorsomorphin (compound C; 10 mg/kg, intravenously once) dihydrochloride treatment leads to a 60% increase in total serum iron concentrations, reduces basal levels of hepcidin expression and increases serum iron concentrations in adult mice[3].
    Dorsomorphin (0.2 mg/kg, i.v., 30 min before LPS injection) dihydrochloride reduces ICAM-1 and VCAM-1 expression in LPS-injected rat aorta[4].
    Dorsomorphin (25 mg/kg; i.p. injection, in male BALB/c mice) dihydrochloride treatment before lipopolysaccharide (LPS) injection significantly reduces lethality in contrast to animals treated with LPS challenge only[5].

    Animal Model:Wild-type (WT) C57BL/6 adult mice that are fed a standard iron-replete diet express high levels of hepcidin[3].
    Dosage:10 mg/kg.
    Administration:Intravenously once.
    Result:Led to a 60% increase in total serum iron concentrations.
    Effective in reducing basal levels of hepcidin expression and increasing serum iron concentrations in adult mice.
    Animal Model:Male Sprague-Dawley rats, 8 weeks of age (body weight 230-250 g)[4].
    Dosage:0.2 mg/kg.
    Administration:I.V., 30 min before LPS injection.
    Result:Reduced ICAM-1 and VCAM-1 expression in LPS-injected rat aorta.
    Animal Model:Male BALB/c mice at 6-7 weeks of age weighing 20-22 g[5]
    Dosage:25 mg/kg
    Administration:Injection i.p.; 60 min before LPS challenge
    Result:Treatment of mice with 25 mg/kg before LPS injection significantly reduced lethality in contrast to animals treated with LPS challenge only.
  • IC 50 AMPK: 109 nM (Ki); ACVR1; BMPR1A; ALK6; Autophagy
  • storage Room temperature (desiccate)
BML-275 Preparation Products And Raw materials
Raw materials
Preparation Products
BML-275 Suppliers
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BML-275 Spectrum
1219168-18-9, BML-275Related Search:
  • PI3K
  • mTOR
  • Akt
  • Inhibitors
  • PI3K/Akt/mTOR
  • 抑制剂
  • 药靶配体
  • 小分子抑制剂，天然产物
  • 高纯试剂
  • C24H25N5O2ClH
  • C24H27Cl2N5O
  • 化合物DORSOMORPHIN DIHYDROCHLORIDE,10 MM DMSO 溶液
  • DORSOMORPHIN DIHYDROCHLORIDE,AMP-KINASE抑制剂
  • NUTLIN-3A (REBEMADLIN)
  • 化合物 DORSOMORPHIN DIHYDROCHLORIDE
  • BML-275盐DORSOMORPHIN二盐酸盐
  • 6-(4-(2-(哌啶-1-基)乙氧基)苯基)-3-(吡啶-4-基)吡唑并[1,5-A]嘧啶 二盐酸盐
  • DORSOMORPHIN二盐酸盐
  • 物质C盐酸盐
  • 6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶二盐酸盐
  • BML-275 HCL,物质C盐酸盐
  • 1219168-18-9
  • Dorsomorphin dihydrochloride, 10 mM in DMSO
  • Dorsomorphin dihydrochloride, AMP-kinase inhibitor
  • Nutlin-3a (Rebemadlin)
  • Dorsomorphin Dihydrochloride BML-275 BML275
  • Dorsomorphin (Compound C) dihydrochloride
  • Compound C 2HCl
  • Dorsomorphin HCl
  • BML-275; COMPOUND C; BML275; BML 275
  • CS-1883
  • 6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE;DIHYDROCHLORIDE
  • BML-275;COMPOUND C;BML275;BML 275;BML-275 DIHYDROCHLORIDE;COMPOUND C DIHYDROCHLORIDE;BML275 DIHYDROCHLORIDE;BML 275 DIHYDROCHLORIDE
  • BML-275 Dorsomorphin 2HCL
  • Dorsomorph
  • DORSOMORPHIN 2HCL;BML275.HCL;COMPOUND C
  • DORSOMORPHIN (COMPOUND C) 2HCL
  • Compound C dihydrochloride
  • BML-275(2HCL)
  • Dorsomorphin(BML-275)dihydrochloride
  • BML-275 dihydrochloride
  • 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2)
  • Dorsomorphin-2HCl BML-275
  • 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2) Dorsomorphin 2HCl
  • BML-275,Compound C
  • DorsoMorphin, Dihydrochloride Salt, >99%
  • dorsoMorphin (Hydrochloride)
  • Dorsomorphin 2HCl (BML-275 2HCl)

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