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SB 431542

SB 431542 Structure
SB 431542
  • CAS No.301836-41-9
  • Chemical Name:SB 431542
  • CBNumber:CB5360318
  • Molecular Formula:C22H16N4O3
  • Formula Weight:384.39
  • MOL File:301836-41-9.mol
SB 431542 Property
  • Melting point 214 °C(dec.)
  • Boiling point 662.4±55.0 °C(Predicted)
  • Density 1.373
  • Flash point 354.4℃
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility DMSO: 10 mg/mL, soluble
  • form powder
  • pka 10.14±0.10(Predicted)
  • color Yellow
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
  • InChIKey FHYUGAJXYORMHI-UHFFFAOYSA-N
  • FDA UNII E1557V1V0N
  • UNSPSC Code 51111800
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • HS Code  :29349990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P280-P305+P351+P338-P362+P364
SB 431542 Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: S4317
  • Product name : SB 431542 hydrate
  • Purity: ≥98% (HPLC), powder
  • Packaging: 5MG
  • Price: ₹17947.85
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 616464
  • Product name : InSolution TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
  • Purity: The InSolution TGF-β RI Kinase Inhibitor VI, SB431542 controls the biological activity of TGF-β RI. Primarily used for Phosphorylation & Dephosphoryla
  • Packaging: 5MG
  • Price: ₹13100
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 616461
  • Product name : TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
  • Purity: TGF-β RI Kinase Inhibitor VI, SB431542, CAS 301836-41-9, is a cell-permeable inhibitor of SMAD2 phosphorylation. Inhibits the activity of ALK4 and ALK
  • Packaging: 5MG
  • Price: ₹16960.01
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: B4003
  • Product name : SB 431542
  • Purity: 
  • Packaging: 25MG
  • Price: ₹7400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: B4003
  • Product name : SB 431542
  • Purity: 
  • Packaging: 100MG
  • Price: ₹17500
  • Updated: 2022/05/26
  • Buy: Buy

SB 431542 Chemical Properties,Usage,Production

  • Description SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.
  • Uses SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells. Potent TGF-beta inhibitor.
  • Definition ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.
  • General Description A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 μM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 ≥10 μM in the presence of 10 μM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).
  • Biological Activity Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.
  • Biochem/physiol Actions SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.
  • storage Room temperature
  • References 1) Laping et al. (2002), Inhibition of transforming growth factor (TGF-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I kinase activity: SB-431542; Mol. Pharmacol., 62 58 2) Inman et al. (2002), SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5 and ALK7; Mol. Pharmacol., 62 65 3) Matsuyama et al. (2003), SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells; Cancer Res., 63 7791 4) Watabe et al. (2003), TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells; J. Cell Biol., 163 1303 5) Stanslowsky et al. (2014), Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells; Stem Cell Res. Ther., 5 35
SB 431542 Preparation Products And Raw materials
Raw materials
Preparation Products
SB 431542 Suppliers
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SB 431542 Spectrum
301836-41-9, SB 431542Related Search:
  • Signalling
  • Protein Kinase
  • TGF-beta
  • Smad
  • Anti-cancer&immunity
  • Inhibitors
  • 抑制剂
  • 生化试剂
  • 药靶配体
  • 小分子
  • 试剂盒-细胞分析试剂盒
  • 细胞生物学试剂
  • 抗肿瘤及免疫抑制剂
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • Cytokines and Growth Factors
  • Cytokines, Growth Factors and Hormones
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • C22H16N4O3xH2O
  • SB-431542 |CAS 301836-41-9
  • SB-431542(标准型)
  • 化合物SB 431542,10 MM DMSO 溶液
  • SB431542 (DMSO SOLUTION),ALK抑制剂
  • SB-431542,STERILE-FILTERED
  • SB431542,ALK抑制剂
  • SB431542 (TGF-Β/SMAD抑制剂)
  • ALK4抑制剂
  • 化合物SB 431542
  • SB431542游离
  • 4-(4-(苯并[D][1,3]二恶茂-5-基)-5-(吡啶-2-基)-1H-咪唑-2-基)苯甲酰胺
  • SB 431542, 一种有效的选择性ALK5抑制剂
  • SB-431542 颜色较差
  • SB431542水合物
  • 4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯酰胺
  • 4-[4-(1,3-苯并二氧戊环-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]苯甲酰胺
  • ALK5和ALK4抑制剂(SB-431542)
  • 4-[4-(3,4-亚甲二氧基苯基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺
  • 4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯酰胺水合物
  • 301836-41-9
  • TGF-β RI Kinase Inhibitor VI, SB431542
  • SB-431542, 10 mM in DMSO
  • SB 431542/4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
  • SB431542, ALK inhibitor
  • SB431542 (DMSO solution), ALK inhibitor
  • SB-431542, Sterile-Filtered
  • SB-431542 (Standard)
  • Transforming growth factor beta receptors,inhibit,TGF-β Receptor,SB-431542,SB431542,Inhibitor
  • TGF-β RI Kinase Inhibitor VI SB431542 SB-431542
  • 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide
  • SB 431542USP/EP/BP
  • SB 431542, 98%, a potent and selective inhibitor of ALK5
  • 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
  • CS-89
  • InSolution TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
  • TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
  • 4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imid

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