ChemicalBook > CAS DataBase List > CX-4945

CX-4945

CX-4945 Structure
CX-4945
  • CAS No.1009820-21-6
  • Chemical Name:CX-4945
  • CBNumber:CB62473893
  • Molecular Formula:C19H12ClN3O2
  • Formula Weight:349.77
  • MOL File:1009820-21-6.mol
CX-4945 Property
  • Boiling point 568.5±50.0 °C(Predicted)
  • Density 1.490
  • storage temp. Store at -20°C
  • solubility ≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
  • form Orange powder.
  • pka 2.96±0.30(Predicted)
  • color Yellow to orange
  • FDA UNII C6RWP0N0L2
Safety
  • HS Code  :29339900
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

CX-4945 Chemical Properties,Usage,Production

  • Uses CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.
  • Biological Activity cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]
  • in vivo

    Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models[1].

  • IC 50 CK2α: 1 nM (IC50); CK2α': 1 nM (IC50)
  • References [1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.
CX-4945 Preparation Products And Raw materials
Raw materials
Preparation Products
CX-4945 Suppliers
Global(174)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Biochempartner
  • Tel：0086-13720134139
  • Email：candy@biochempartner.com
  • Country：CHINA
  • ProdList：965
  • Advantage：58
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
  • Country：United States
  • ProdList：63687
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
CX-4945 Spectrum
1009820-21-6, CX-4945Related Search:
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 医用原料
  • 抑制剂
  • 化工试剂
  • 药靶配体
  • 合成有机化合物配体
  • 细胞生物学试剂
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • 化合物SILMITASERTIB,10 MM DMSO 溶液
  • 化合物 SILMITASERTIB
  • 5-[(3-氯苯基)氨基]苯并[C][2,6]萘啶-8-甲酸
  • CX-4945 (SILMITASERTIB),CK2抑制剂
  • 4 - 二 - 叔丁基苯基)磷酸酯
  • SILMITASERTIB, 一种高活性ATP竞争性CK2抑制剂
  • CK2抑制剂(CX-4945)
  • 5-[(3-氯苯基)氨基]-苯并[C]-2,6-萘啶-8-羧酸
  • 5-((3-氯苯基)胺)苯并-[C][2,6]萘啶-8-羧酸
  • 1009820-21-6
  • Silmitasertib, 10 mM in DMSO
  • SPIROBIINDANE CX-4945
  • CX-4945 Silmitasertib CX4945
  • CX-4945 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic
  • 4-di-tert-butylphenyl)phosphate
  • Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]-
  • mitasertib (CX-4945)
  • SILMITASERTIB; CX 4945; CX4945
  • CS-1985
  • CX4945 CX-4945; CX 4945; SILMITASERTIB.
  • Silmitasertib, 98%, a potent and selective ATP-competitive CK2 inhibitor
  • CX-4945 (SILMITASERTIB);CX 4945; CX4945
  • CX-4945, >=98%
  • 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib)
  • Silmitasertib(CX-4945)
  • CX-4945, CX4945
  • CX-4945 Silmitasertib
  • Silmitasertib
  • CX-4945
  • 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid

Home

My