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PD 0332991 HCl

PD 0332991 HCl Structure
PD 0332991 HCl
  • CAS No.827022-32-2
  • Chemical Name:PD 0332991 HCl
  • CBNumber:CB22593007
  • Molecular Formula:C24H30ClN7O2
  • Formula Weight:484
  • MOL File:827022-32-2.mol
PD 0332991 HCl Property
  • storage temp. = -70C
  • solubility ≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic
  • form Yellow liquid
  • color Light yellow to yellow
  • Water Solubility water: 10mg/mL
  • FDA UNII BKC4F3Q5XL
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • HS Code  :29399990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
PD 0332991 HCl Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 5.30487
  • Product name : StemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem
  • Purity: A cell-permeable, brain permeant, potent, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC?? = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk
  • Packaging: 5MG
  • Price: ₹12940
  • Updated: 2022/06/14
  • Buy: Buy

PD 0332991 HCl Chemical Properties,Usage,Production

  • Description PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.
  • General Description A cell-permeable, orally available and brain permeant, non-toxic pyridopyrimidinone compound that acts as a potent, selective, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC50 = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk6/D2, respectively). Hence, it reduces retinoblastoma protein phosphorylation at Ser780/Ser795 (IC50 = 66 nM in MDA-435 cells) and arrests cell cycle at G1 phase. Acts as a cytostatic agent, but does induce apoptotic cell death when used alone. However, it potentiates the cytotoxicity of dexamethasone (>Cat. No. 265005), bortezomib (>Cat. No. 504314), and tamoxifen (Cat. No. 579000) in estrogen receptor (ER)-positive cell lines. Exhibits only a trivial inhibitory activity towards Cdk2/E2, Cdk2/A, Cdk1/B and Cdk5/p25 in a 36-kinase panel (IC50 >10 μM). Improves endoderm differentiation of late G1-human embryonic stem cells expressing Smad2 or Smad3 (~ 750 nM) and further enhances endoderm differentiation into hepatic and pancreatic progenitor cells. Shown to regress the growth of human breast tumor xenografts in murine models (~150 mg/kg, p.o., daily).
  • Biochem/physiol Actions Cell permeable: yes
  • target CDK4/cyclin D1
  • References [1] ivan diaz-padilla, lillian l. siu and ignacio duran. cyclin-dependent kinase inhibitors as potential targeted anticancer agents. invest new drugs. 2009, 27: 586–594.
    [2] richard s finn, judy dering, dylan conklin, ondrej kalous, david j cohen, amrita j desai, charles ginther, mohammad atefi, isan chen, camilla fowst, gerret los and dennis j slamon. pd 0332991, a selective cyclin d kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. breast cancer research. 2009, 11: r77.
PD 0332991 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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PD 0332991 HCl Spectrum
827022-32-2, PD 0332991 HClRelated Search:
  • Inhibitors
  • 抑制剂
  • 生物试剂
  • 药靶配体
  • 原料药
  • 细胞生物学试剂
  • 原料药-API
  • 小分子抑制剂，天然产物
  • 细胞周期
  • C24H29N7O2ClH
  • C24H30ClN7O2
  • C24H29N7O2HCl
  • 帕博西林盐酸盐/827022-32-2
  • 帕博西尼布杂质22 盐酸盐
  • 帕博西尼布杂质20 盐酸盐
  • PD0332991 盐酸盐
  • 6-乙酰基-8-环戊基-5-甲基-2-((5-(哌嗪-1-基)吡啶-2-基)氨基)吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
  • 哌柏西利盐酸盐
  • 帕博西尼盐酸盐
  • 6-乙酰基-8-环戊基-5-甲基-2-[[5-(哌嗪-1-基)吡啶-2-基]氨基]-8H-吡啶并[2,3-D]嘧啶-7-酮盐酸盐
  • CDK4和CDK6抑制剂
  • 帕博西尼盐酸盐, 一种高度选择性的CDK4/6抑制剂
  • 帕布昔利布标准品025
  • 盐酸帕布昔利布
  • 2-[[5-(1-哌嗪基)-2-吡啶基]氨基]-5-甲基-6-乙酰基-8-环戊基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
  • 帕博西林
  • PALBOCICLIB 盐酸盐
  • 帕布昔利布盐酸盐
  • 帕博西林盐酸盐
  • 827022-32-2
  • PD-0332991 HCl (Palbociclib HCl)
  • StemSelect PD 0332991
  • PD 0332991 hydrochloride(1:1)
  • Palbociclib Impurity 20 HCl
  • Palbociclib Impurity 22 HCl
  • PALBOCICLIB (PD-0332991) (HCL SALT)
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride1
  • TIANFU-CHEM CAS:827022-32-2 PD 0332991 HCl
  • Palbociclib (monohydrochloride)
  • Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-me...
  • PD 0332991 HCl USP/EP/BP
  • PD 0332991; PD-0332991; PD0332991; PD0332991; PD332991; PD-332991; PD 332991; PALBOCICLIB, BRAND NAME: IBRANCE
  • Palbociclib, brand name: Ibrance
  • PALBOCICLIB;PD-0332991 HYDROCHLORIDE;PD0332991 HYDROCHLORIDE;PD 0332991 HYDROCHLORIDE
  • Palbociclib hydrochloride, 99%, a highly selective CDK4/6 inhibitor
  • PD 0332991;PD-0332991
  • Palbociclib-019-HCl
  • CS-365
  • PD 0332991 (Palbociclib) HCl
  • Palbociclib-025
  • PD 0332991 HCl (Palbociclib)
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)pyrido[2,3-d]pyrimidin-
  • 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one hydrochloride
  • Palbociclib (PD-0332991) hydrochloride
  • Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-,monohydrochloride
  • 6-acetyl-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one hydrochloride
  • Palbociclib (PD-0332991) HCl

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