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pyridine-3-sulfonyl chloride

pyridine-3-sulfonyl chloride Structure
pyridine-3-sulfonyl chloride
  • CAS No.16133-25-8
  • Chemical Name:pyridine-3-sulfonyl chloride
  • CBNumber:CB5153121
  • Molecular Formula:C5H4ClNO2S
  • Formula Weight:177.61
  • MOL File:16133-25-8.mol
pyridine-3-sulfonyl chloride Property
  • Melting point 144 °C
  • Boiling point 284℃
  • Density 1.488
  • refractive index n20/D 1.556
  • Flash point 126℃
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Chloroform (Sparingly), Methanol (Slightly)
  • form liquid
  • pka -1.77±0.11(Predicted)
  • color Colourless to light yellow
  • Stability Moisture Sensitive
  • InChI InChI=1S/C5H4ClNO2S/c6-10(8,9)5-2-1-3-7-4-5/h1-4H
  • InChIKey CDRNYKLYADJTMN-UHFFFAOYSA-N
  • SMILES C1=NC=CC=C1S(Cl)(=O)=O
  • LogP 1.75
  • CAS DataBase Reference 16133-25-8(CAS DataBase Reference)
  • UNSPSC Code 12352200
  • NACRES NA.22
Safety
  • Hazard Codes  :Xi,C
  • Risk Statements  :34-43
  • Safety Statements  :26-36/37/39-45
  • RIDADR  :3261
  • WGK Germany  :3
  • HazardClass  :IRRITANT
  • PackingGroup  :Ⅲ
  • HS Code  :2933399990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H314-H317
  • Precautionary statements P280-P305+P351+P338-P310
pyridine-3-sulfonyl chloride Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: CDS013908
  • Product name : 3-pyridinesulfonyl chloride hydrochloride
  • Purity: AldrichCPR
  • Packaging: 250MG
  • Price: ₹10760.05
  • Updated: 2022/06/14
  • Buy: Buy

pyridine-3-sulfonyl chloride Chemical Properties,Usage,Production

  • Chemical Properties It is a colorless, transparent liquid. It is extremely unstable when in contact with water and is easily hydrolyzed to generate pyridine-3-sulfonic acid and hydrochloric acid, which makes it lose its reactivity.
  • Uses 3-pyridinesulfonyl Chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
  • Application Pyridine-3-sulfonyl chloride is an essential medical intermediate and is widely applied to the synthesis of medicines, wherein the pyridine-3-sulfonyl chloride is mainly used for preparing TAK-438 (vonoprazan fumarate), which is a novel orally active potassium-competitive acid blocker, developed as an antisecretory drug.
  • Toxicology Pyridine-3-sulfonyl chloride causes burns of eyes, skin and mucous membranes. Contact with water liberates toxic gas.
  • Synthesis Add thionyl chloride to the water, cool to about 0-5°C, and add cuprous chloride. Fluoboric acid diazonium salt was added to the solution and reacted at 0-5°C overnight. The reaction solution was extracted with dichloromethane, combining the organic layers. The organic layer was washed once with saturated aqueous sodium bicarbonate solution, once with water, and finally once with saturated brine. The product was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated to remove methylene chloride to obtain the product pyridine-3-sulfonyl chloride with a yield of 90.7%.
    pyridine-3-sulfonyl chloride
pyridine-3-sulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
pyridine-3-sulfonyl chloride Suppliers
Global(524)Suppliers
  • Supplier：
    Hangzhou ICH Biofarm Co., Ltd
  • Tel：+86-0571-28186870;<br/>+undefined8613073685410
  • Email：sales@ichemie.com
  • Country：China
  • ProdList：1015
  • Advantage：58
pyridine-3-sulfonyl chloride Spectrum
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