ChemicalBook > CAS DataBase List > 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Structure
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
  • CAS No.881677-11-8
  • Chemical Name:5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
  • CBNumber:CB02680972
  • Molecular Formula:C16H11FN2O3S
  • Formula Weight:330.33
  • MOL File:881677-11-8.mol
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Property
  • Boiling point 563.7±60.0 °C(Predicted)
  • Density 1.37±0.1 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Chloroform (Slightly), DMSO (Slightly)
  • form Solid
  • pka -0.34±0.11(Predicted)
  • color Pale Brown to Light Brown
  • InChI InChI=1S/C16H11FN2O3S/c17-15-6-2-1-5-14(15)16-8-12(11-20)10-19(16)23(21,22)13-4-3-7-18-9-13/h1-11H
  • InChIKey IXCSYEVJOAWXRH-UHFFFAOYSA-N
  • SMILES N1(S(C2=CC=CN=C2)(=O)=O)C(C2=CC=CC=C2F)=CC(C=O)=C1
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Usage,Production

  • Chemical Properties Pale Brown to Light Brown Solid.
  • Uses 3-Des-N-methylmethanamine Vonoprazan-3-carbaldehyde is an impurity of Vonaprazan (V767010) a novel potassium-competitive acid blocker for the treatment of acid-related diseases.
  • Synthesis 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde is prepared by the reaction of 3-pyridinesulfonyl Chloride and 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde. The specific synthesis steps are as follows:
    Take 10.0g (52.86mmol) of compound, 5.9g (58.15mmol) of triethylamine and 100mL of dichloromethane, cool the system to 0°C, add dropwise a dichloromethane solution (100mL) of compound G (58.15mmol), and add dropwise After completion, the system was reacted at room temperature for 6 hours, 100mL of water was added and washed twice, the organic phase was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 16.4g of 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde, with a yield of 93.8%.
    5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde synthesis
  • Solubility in organics Chloroform (Slightly), DMSO (Slightly)
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Suppliers
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  • Supplier：
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5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Spectrum
881677-11-8, 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehydeRelated Search:
  • 881677-11-8
  • 抑制剂
  • 系列2
  • 沃诺拉赞系列
  • 高端化学
  • 原料药
  • 化学试剂
  • 医药化工
  • 沃诺拉赞系列产品
  • 原料药及中间体
  • 医药原料
  • 沃诺拉赞中间体
  • 化工中间体
  • 杂质对照品
  • 系列1
  • 化学中间体
  • 医用原料
  • 沃诺拉赞杂质
  • 对照品-杂质对照品
  • 富马酸沃诺拉赞中间体
  • 中间体
  • 消化
  • 富马酸沃诺拉赞 / Vonoprazan fumarate
  • 医药中间体
  • 化合物 5-(2-FLUOROPHENYL)-1-(PYRIDIN-3-YLSULFONYL)-1H-PYRROLE-3-CARBALDEHYDE
  • 1H-吡咯-3-羧醛,5-(2-氟苯基)-1-(3-吡啶基磺酰)
  • 伏诺拉生系列中间体
  • 沃诺拉赞杂质67
  • 5-(2-氟苯基)-1-(3-吡啶基磺酰基)-1H-吡咯-3-甲醛
  • TAK438中间体 5
  • 5-(2-氟苯基)-1-[(吡啶-3-基)磺酰基]-1H-吡咯-3-甲醛(N-2)
  • 5-(2-氟苯基)-1-(吡啶-3-基磺酰基)-1H-吡咯-3-甲醛(沃诺拉赞杂质)
  • 伏诺拉生标准品026
  • 沃诺拉赞标准品026
  • 5-(2-氟苯基)-1-(吡啶-3-磺酰基)-1H-吡咯-3-甲腈
  • 富马酸沃诺拉赞中间体II
  • 沃诺拉赞中间体:5-(2-氟苯基)-1-[(吡啶-3-基)磺酰基]-1H-吡咯-3-甲醛
  • 沃诺拉赞 N-1
  • 富马酸沃诺拉赞杂质5
  • 沃诺拉赞中间体
  • 文诺普兰标准品026
  • 5-(2-氟苯基)-1-(吡啶-3-取代磺酰基)-1H-吡咯-3-甲醛
  • 5-(2-氟苯基)-1-[(吡啶-3-基)磺酰基]-1H-吡咯-3-甲醛
  • 富马酸氟呐普拉赞中间体
  • 5-(2-氟苯基)-1-(吡啶-3-磺酰基)-1H-吡咯-3-甲醛
  • 富马酸沃诺拉赞中间体2
  • 881677-11-8
  • 5-(2-FluorophenyI)-1-[(py ridin-3-yl)sulfonyl]-1H-p yrrole-3-carboxaldehyde
  • Sulfonyl aldehyde Impurity of Vonoprazan
  • 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carba
  • 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole
  • 5-(2-Fluoropheny1)-1-[( pyridin -3- yl ) sulfonyl ]-1H- pyrrole -3- carboxaldehyde
  • Vonolazan impurity 12
  • 5- (2-Fluorophenyl)-1- (pyridine-3-sulphonyl)-1-H-pyrrole-3-carbaldehyde
  • TAK438 Intermediate 5
  • 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde (Vonoprazan Impurity)
  • Vonoprazan N -1
  • 5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde

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