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Ginsenoside Rb1

Ginsenoside Rb1 Structure
Ginsenoside Rb1
  • CAS No.41753-43-9
  • Chemical Name:Ginsenoside Rb1
  • CBNumber:CB7237661
  • Molecular Formula:C54H92O23
  • Formula Weight:1109.29
  • MOL File:41753-43-9.mol
Ginsenoside Rb1 Property
  • Melting point 197.5°C
  • Boiling point 766.35°C (rough estimate)
  • Density 1.0971 (rough estimate)
  • refractive index 1.6500 (estimate)
  • storage temp. 2-8°C
  • solubility methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to faintly yellow
  • pka 12.85±0.70(Predicted)
  • form Solid
  • color Off-White to Pale Beige
  • biological source plant root (Panax ginseng)
  • Stability Hygroscopic
  • InChIKey GZYPWOGIYAIIPV-VOKNSFSUNA-N
  • LogP 2.900 (est)
  • CAS DataBase Reference 41753-43-9(CAS DataBase Reference)
  • FDA UNII 7413S0WMH6
  • UNSPSC Code 85151701
  • NACRES NA.25
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P501
Ginsenoside Rb1 Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: G0777
  • Product name : Ginsenoside-Rb1 from Panax ginseng (Korean ginseng) root
  • Purity: triterpenoid saponin
  • Packaging: 5MG
  • Price: ₹35451.88
  • Updated: 2022/06/14
  • Buy: Buy

Ginsenoside Rb1 Chemical Properties,Usage,Production

  • Description Ginsenoside Rb1, a glycosylated PPD type ginsenoside with two sugars linked to C-3 and two sugars linked to C-20, is the major active constituent of American ginseng. Studies have demonstrated the anti-aging effects of ginsenoside Rb1 at both animal and cell levels. 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (20GPPD) is the major ingredient of ginsenoside Rb1, which has been shown to increase HAS2 expression by phosphorylating ERK and AKT signaling in human keratinocytes in a dose-dependent manner in vitro.
  • Uses A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects.
  • Uses Reference standard in the analysis of herbal medicinal products.
  • Definition ChEBI: Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd.
  • benefits Ginsenoside Rb1 (G-Rb1) is a tetracyclic triterpenoid mainly obtained from the roots or stems of Panax notoginseng and ginseng by extraction and purification. It is one of the main bioactive compounds of ginseng with minimal toxicity and neurotrophic and neuroprotective effects on brain injury. G-Rb1 promotes hippocampal nerve regeneration, enhances learning and memory, and has anti-aging and anti-fatigue effects. In addition, it activates antioxidants, stimulates the immune system, has anti-apoptotic activity, and maintains cell adenosine triphosphate (ATP) levels[1].
  • General Description Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.
  • Biochem/physiol Actions Triterpene saponin found in ginseng.
  • Safety Profile Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits acrid smoke and irritating fumes.
  • target p38MAPK | JNK | GLUT | Akt | IFN-γ | IL Receptor | GSK-3 | HO-1 | PKA | Estrogen receptor | Progestogen receptor
  • References [1] Shan Wen. “Ginsenoside Rb1 improves energy metabolism after spinal cord injury.” Neural Regeneration Research 18 6 (2023): 1332–1338.
Ginsenoside Rb1 Preparation Products And Raw materials
Raw materials
Preparation Products
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Ginsenoside Rb1 Spectrum
41753-43-9, Ginsenoside Rb1 Related Search:
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  • 人参皂苷系列
  • C60H102O27
  • C54H92O23
  • 41753-53-9
  • GINSENOSIDE RB1,NATURAL TRITERPENOID SAPONIN
  • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-二羟基-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-羟基-4,4,8,10,14-五甲基-17-((S)-6-甲基-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-((((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)庚-5-烯-2-基)十六氢-1H-环戊并[A]菲-3
  • 人参皂基RBL
  • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-二羟基-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-羟基-4,4,8,10,14-五甲基-17-((S)-6-甲基-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-((((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)庚-5-烯-2-基)十六氢-1H-环戊并[A]菲-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4
  • 标准品对照品】GINSENOSIDE RB1

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