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Ginsenoside Rg3

Ginsenoside Rg3 Structure
Ginsenoside Rg3
  • CAS No.14197-60-5
  • Chemical Name:Ginsenoside Rg3
  • CBNumber:CB9713141
  • Molecular Formula:C42H72O13
  • Formula Weight:785.01
  • MOL File:14197-60-5.mol
Ginsenoside Rg3 Property
  • Melting point 315-318°C
  • Boiling point 885.0±65.0 °C(Predicted)
  • Density 1.30
  • storage temp. 2-8°C
  • solubility DMSO: ≥5mg/mL
  • pka 12.85±0.70(Predicted)
  • form powder
  • color white to beige
  • optical activity [α]/D +10 to +20°, c = 1 in methanol
  • InChIKey RWXIFXNRCLMQCD-JBVRGBGGSA-N
  • CAS DataBase Reference 14197-60-5(CAS DataBase Reference)
  • FDA UNII 227D367Y57
  • UNSPSC Code 85151701
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • WGK Germany  :3
  • RTECS  :LY9537300
  • HS Code  :29389090
  • Toxicity :mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330
Ginsenoside Rg3 Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0184
  • Product name : Ginsenoside Rg3
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹12838.45
  • Updated: 2022/06/14
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  • Brand: Sigma-Aldrich(India)
  • Product number: SML0184
  • Product name : Ginsenoside Rg3
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹52620.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 64139
  • Product name : Ginsenoside Rg3
  • Purity: analytical standard
  • Packaging: 10MG
  • Price: ₹27592.93
  • Updated: 2022/06/14
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  • Brand: ottokemi
  • Product number:  G 1238
  • Product name : Ginsenoside
  • Purity: 80%
  • Packaging: 5mg
  • Price: ₹5769
  • Updated: 2022/05/26
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  • Brand: ottokemi
  • Product number:  G 1238
  • Product name : Ginsenoside
  • Purity: 80%
  • Packaging: 25mg
  • Price: ₹23409
  • Updated: 2022/05/26
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Ginsenoside Rg3 Chemical Properties,Usage,Production

  • Description Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg3 induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.
  • Uses Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.
  • Uses Ginsenoside Rg3 has been used to investigate its modulatory effects on delayed rectifier potassium current (IKr) channels in long QT syndrome (LQTS)2-human induced pluripotent stem cells (hiPSC-CMs).
  • Definition ChEBI: (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.
  • Biochem/physiol Actions Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.
  • in vivo

    Ginsenoside Rg3 ((20S)-Rg3) is an Aβ-lowering Natural Compound. APP/PS1 mice are treated with Ginsenoside Rg3 once a day for 4 weeks by intraperitoneal injection (10 mg/kg/day). Aβ ELISA analysis of brain tissues reveal that Ginsenoside Rg3 treatment results in a significant reduction of Aβ40 and Aβ42 in the brain[4].

  • IC 50 Na+ channel: 32.2 μM (IC50); hKv1.4 channel: 32.6 μM (IC50); p65; COX-2; Aβ40; Aβ42
Ginsenoside Rg3 Preparation Products And Raw materials
Raw materials
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    career henan chemical co
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Ginsenoside Rg3 Spectrum
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