11-Deoxy prostaglandin f1alpha

Description

11-deoxy PGF_1α is a synthetic analog of PGF_1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF_1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF_1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF_2α in guinea pigs.

Uses

11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor[1][2].

Definition

ChEBI: 11-Deoxy-PGF1alpha is a prostanoid.

in vivo

References

[1] Broughton BJ, et al., Uterine stimulant action of some omega-chain modified (+)-11-deoxyprostaglandins. Prostaglandins. 1981 Jul;22(1):53-64. DOI:10.1016/0090-6980(81)90053-8
[2] Hall DW, et al., Structure-activity relationships in a series of 11-deoxy prostaglandins. Prostaglandins. 1976 Mar;11(3):573-87. DOI:10.1016/0090-6980(76)90106-4