9alpha, 15S-dihydroxy-11-oxo-prost-13e-en-1-oic-3,3,4,4-d4 acid

Description

Prostaglandin D1-d4 (PGD1-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGD1 by GC- or LC-mass spectrometry. PGD1 is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2.1WARNING This product is not for human or veterinary use.

References

[1] G. L. BUNDY. ChemInform Abstract: Synthesis and Platelet Aggregation Inhibiting Activity of Prostaglandin D Analogues.[J]. ChemInform, 1984, 15 8. DOI: 10.1002/chin.198408306