Description
17-phenyl trinor Prostaglandin F2α ethyl amide-d4 is intended for use as an internal standard for the quantification of 17-phenyl trinor prostaglandin F2α ethyl amide (Item No. 16820) by GC- or LC-MS. 17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series prostaglandin derivative and an agonist of FP receptors.1,2 It induces calcium mobilization in 3T3-L1 fibroblasts expressing the human receptors (EC50 = 2.2 µM).1 Ocular administration of 17-phenyl trinor PGF2α ethyl amide (0.03% w/v) reduces intraocular eye pressure (IOP) in normotensive dogs and ocular hypertensive monkeys.2 Formulations containing 17-phenyl trinor PGF2α ethyl amide have been used in the treatment of open angle glaucoma, ocular hypertension, and eyelash hypotrichosis.WARNING This product is not for human or veterinary use.
References
[1] NAJAM A SHARIF Curtis R K Gary W Williams. Bimatoprost and its free acid are prostaglandin FP receptor agonists[J]. European journal of pharmacology, 2001, 432 2: Pages 211-213. DOI:
10.1016/s0014-2999(01)01486-8[2] D.F WOODWARD PHD. The Pharmacology of Bimatoprost (Lumigan™)[J]. Survey of ophthalmology, 2001, 45: Pages S337-S345. DOI:
10.1016/s0039-6257(01)00224-7
