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PAC1

PAC1 Structure
PAC1
  • CAS No.315183-21-2
  • Chemical Name:PAC1
  • CBNumber:CB71075505
  • Molecular Formula:C23H28N4O2
  • Formula Weight:392.49
  • MOL File:315183-21-2.mol
PAC1 Property
  • Density 1.14
  • storage temp. Store at +4°C
  • solubility DMSO: ≥10mg/mL
  • form solid
  • pka 8.82±0.40(Predicted)
  • color white
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.
  • FDA UNII 9LIS8N0B2C
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335-H400
  • Precautionary statements P261-P273-P305+P351+P338
PAC1 Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: P0115
  • Product name : PAC-1
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹11052.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SAB1301755
  • Product name : ANTI-DUSP2 (C-TERM) antibody produced in rabbit
  • Purity: IgG fraction of antiserum, buffered aqueous solution
  • Packaging: 400μL
  • Price: ₹47796.6
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: P0115
  • Product name : PAC-1
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹36761.7
  • Updated: 2022/06/14
  • Buy: Buy

PAC1 Chemical Properties,Usage,Production

  • Description PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3
  • Uses PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.
  • Biological Activity Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively).
  • storage +4°C
  • References 1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543 2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144 3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545
PAC1 Preparation Products And Raw materials
Raw materials
Preparation Products
PAC1 Suppliers
Global(150)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    Coresyn Pharmatech Co., Ltd.
  • Tel：+86-571-86626709<br/>+86-18157142896
  • Email：cbc@coresyn.com
  • Country：China
  • ProdList：9984
  • Advantage：58
PAC1 Spectrum
315183-21-2, PAC1Related Search:
  • Inhibitors
  • Inhibitor
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 合成有机化合物配体
  • 分子生物试剂-抑制剂激活剂等
  • 小分子抑制剂，天然产物
  • 细胞信号通路抑制剂
  • 小分子抑制剂
  • 细胞凋亡
  • 半胱天冬酶原活化物1
  • 化合物PAC1,10 MM DMSO 溶液
  • PAC-1,CASPASE-3活化剂
  • PAC-1,CASPASE-3激活剂
  • 流式抗体:HUMAN PAC-1 ANTIBODY (PAC-1) FHC33340
  • 流式抗体:HUMAN ADCYAP1R1 ANTIBODY (SAA0130) FHE32810
  • 流式抗体:HUMAN PAC-1 ANTIBODY (PAC-1) FHC33330
  • 流式抗体:HUMAN PAC-1 ANTIBODY (PAC-1), FITC FHC33331
  • N'-(3-烯丙基-2-羟基苄基亚基)-2-(4-苄基哌嗪-1-基)乙酰肼
  • PAC-1, 一种酶原-3 激活剂
  • PAC1(4-(苯基甲基)-1-哌嗪乙酸 2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼)
  • 4-(苯基甲基)-1-哌嗪乙酸 2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼
  • 315183-21-2
  • PAC-1, 10 mM in DMSO
  • PAC-1, caspase-3 activator
  • PAC1（b）
  • N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide
  • PAC-1 (VO-100)
  • PAC1 USP/EP/BP
  • PAC-1 >=98% (HPLC)
  • 1-Piperazineacetic acid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
  • PAC 1 - Procaspase activating compound 1
  • CS-243
  • PAC-1, 98%, a procaspase-3 activatior
  • PAC-1 10MG
  • PAC 1, >=98%
  • Anti-DUSP2 (C-terminal) antibody produced in rabbit
  • DUSP2
  • Dual specificity protein phosphatase PAC-1
  • Dual specificity protein phosphatase 2
  • ANTI-DUSP2 (C-TERM) antibody produced in rabbit
  • PACAP receptor 1
  • PAC1-R
  • Pac1 receptors
  • Pac1 receptor
  • ADCYAP1R1
  • 1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide
  • (4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide
  • PAC 1 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
  • 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1
  • (E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide
  • Procaspase activating coMpound 1
  • PAC-1,PAC1
  • 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
  • PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide
  • 4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
  • PAC1

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