ChemicalBook > CAS DataBase List > AC-DEVD-CHO

AC-DEVD-CHO

CAS No.169332-60-9
Chemical Name:AC-DEVD-CHO
CBNumber:CB6488321
Molecular Formula:C20H30N4O11
Formula Weight:502.47
MOL File:169332-60-9.mol

AC-DEVD-CHO Property

Boiling point 1021.1±65.0 °C(Predicted)
Density 1.374±0.06 g/cm3(Predicted)
RTECS EK7643000
storage temp. -20°C
solubility H₂O: 1 mg/mL
form powder
pka 4.19±0.10(Predicted)
color white
biological source synthetic
Water Solubility H2O: 1mg/mL
Sensitive Moisture Sensitive
UNSPSC Code 12352209
NACRES NA.77

Safety

WGK Germany :3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P305+P351+P338

AC-DEVD-CHO Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: A0835
Product name : N-Acetyl-Asp-Glu-Val-Asp-al
Purity: ≥95%, powder
Packaging: 1MG
Price: ₹14581.28
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: A0835
Product name : N-Acetyl-Asp-Glu-Val-Asp-al
Purity: ≥95%, powder
Packaging: 5MG
Price: ₹48615.08
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 235420
Product name : Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem
Purity: The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is prim
Packaging: 1MG
Price: ₹14049.99
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: 235420
Product name : Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem
Purity: The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 5MG
Price: ₹44200.01
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 235420
Product name : Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem
Purity: The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is prim
Packaging: 5MG
Price: ₹44200.01
Updated: 2022/06/14
Buy: Buy

AC-DEVD-CHO Chemical Properties,Usage,Production

Uses Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase
Uses N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.
Definition ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.
General Description N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.
Biochem/physiol Actions N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.
in vivo
Compare with model group, in CI group, the concentrations of serum BUN are decreased significantly at all time points after operation and those of Cr are decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 are decreased and those of IL-10 are elevated significantly at all time points. [TNF-α (μg/L) 6 hours: 436.2±64.2 vs. 653.6±8.9, 12 hours: 233.4±85.4 vs. 579.7±137.1, 24 hours: 151.0±90.3 vs. 551.0±119.8, IL-6 (μg/L) 6 hours: 1033.2±345.8 vs. 1 595.3±159.4, 12 hours: 366.3±68.3 vs. 1 330.7±249.8, 24 hours: 241.2±208.4 vs. 815.3±572.7, IL-10 (μg/L) 6 hours: 33.6±10.4 vs. 26.6±4.5, 12 hours: 37.2±5.0 vs. 24.5±4.3, 24 hours: 38.3±5.5 vs. 18.2±1.6, all P<0.05]; the renal cell apoptosis rates are decreased significantly at all time points: apoptosis rates 6 hours: (13.9±3.2)% vs. (18.3±1.4)%, 12 hours: (10.5±3.6)% vs. (15.9±3.5)%, 24 hours: (8.4±1.8)% vs.(12.5±2.1)%^[5].
IC 50 Caspase 3: 0.23 nM (Ki); Caspase-8: 0.92 nM (Ki); Caspase-7: 1.6 nM (Ki); Caspase-10: 12 nM (Ki); Caspase-1: 18 nM (Ki); Caspase-6: 31 nM (Ki); Caspase-9: 60 nM (Ki); Caspase-4: 132 nM (Ki); Caspase-5: 205 nM (Ki); Caspase-2: 1710 nM (Ki)