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AC-IETD-CHO

AC-IETD-CHO Property

Safety

Hazard and Precautionary Statements (GHS)

AC-IETD-CHO Chemical Properties,Usage,Production

Uses Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].
Biological Activity Cell permeable: yes', 'Primary Target
caspase-8', 'Product does not compete with ATP.', 'Reversible: yes
References [1] Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17. DOI:10.1093/toxsci/58.1.109
[2] Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. DOI:10.1046/j.1525-1373.2000.22518.x

AC-IETD-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

AC-IETD-CHO Suppliers

Global(82)Suppliers

AC-IETD-CHO Spectrum

191338-86-0, AC-IETD-CHORelated Search:

Caspases/Apoptosis
peptides
Pepetides
醛肽
抑制剂
定制多肽
BioChemical
Apoptosis and Cell Cycle
Caspases
Caspase 3
Cell Signaling and Neuroscience
Cell Biology
Inhibitors
C21H34N4O10
606613
化合物 AC-IETD-CHO
CASPASE 8抑制剂AC-IETD-CHO
乙酰基-异亮氨酰-谷氨酰-苏氨酰-天冬氨醛
N-乙酰基-异亮氨酰-谷氨酰-苏氨酰-天冬氨醛
191338-86-0
caspase-8 inhibitor inhibitor
L-Threoninamide, N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-
AC-IETD-CHO
GRANZYME B INHIBITOR II
GRANZYME B INHIBITOR (ALDEHYDE)
IETD-CHO, CELL-PERMEABLE
CASPASE-3 PROCESSING ENZYME INHIBITOR I (ALDEHYDE)
CASPASE-8 INHIBITOR I, CELL-PERMEABLE
CASPASE-8 INHIBITOR I
CASPASE 8 INHIBITOR 1
CASPASE-8 / CASPASE-3 PROCESSING ENZYME INHIBITOR (ALDEHYDE)
CASPASE 6/CASPASE 8 INHIBITOR W-1
CASPASE-3 PROCESSING ENZYME INHIBITOR (ALDEHYDE)
AC-IETD-ALDEHYDE
AC-ILE-GLU-THR-ASP-H (ALDEHYDE)
AC-ILE-GLU-THR-ASP-CHO
AC-ILE-GLU-THR-ASP-ALDEHYDE (PSEUDO ACID)
AC-ILE-GLU-THR-ASP-ALDEHYDE
N-Acetyl-Ile-Glu-Thr-Asp-al
Acetyl-isoleucyl-glutamyl-threonyl-aspartal
N-ACETYL-ILE-GLU-THR-ASP-CHO (ALDEHYDE)
ACETYL-L-ISOLEUCYL-L-GLUTAMYL-L-THREONYL-L-ASPART-1-AL
AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-ILE-GLU-THR-ASP-CHO
GRANZYME B INHIBITOR II, CELL-PERMEABLE