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T-2 TOXIN

T-2 TOXIN Structure
T-2 TOXIN
  • CAS No.21259-20-1
  • Chemical Name:T-2 TOXIN
  • CBNumber:CB6469458
  • Molecular Formula:C24H34O9
  • Formula Weight:466.53
  • MOL File:21259-20-1.mol
T-2 TOXIN Property
  • Melting point 151.5℃
  • alpha D26 +15° (c = 2.58 in ethanol)
  • Boiling point 489.35°C (rough estimate)
  • Density 1.1942 (rough estimate)
  • refractive index 1.6230 (estimate)
  • Flash point 2 °C
  • storage temp. −20°C
  • solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
  • form powder
  • pka 13.24±0.70(Predicted)
  • color white
  • Merck 13,9872
  • FDA UNII I3FL5NM3MO
  • IARC 3 (Vol. 31, Sup 7) 1987
  • UNSPSC Code 85151701
  • NACRES NA.24
Safety
  • Hazard Codes  :T+,T,Xn,F
  • Risk Statements  :26/27/28-38-36-20/21/22-11
  • Safety Statements  :28-36/37-45-36-26-16-36/37/39-22
  • RIDADR  :UN 3462 6.1/PG 1
  • WGK Germany  :3
  • RTECS  :YD0100000
  • F  :10-21
  • HazardClass  :6.1(a)
  • PackingGroup  :I
  • HS Code  :29329990
  • Hazardous Substances Data :21259-20-1(Hazardous Substances Data)
  • Toxicity :LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)
  • NFPA 704:
    0
    4 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H310+H330-H315
  • Precautionary statements P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
T-2 TOXIN Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: 34071
  • Product name : T2-Toxin solution
  • Purity: 100?μg/mL in acetonitrile, analytical standard
  • Packaging: 2ML
  • Price: ₹63919.8
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 33947
  • Product name : T-2 Toxin
  • Purity: reference material
  • Packaging: 5MG
  • Price: ₹51711.03
  • Updated: 2022/06/14
  • Buy: Buy

T-2 TOXIN Chemical Properties,Usage,Production

  • Description T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.
  • Chemical Properties White powder
  • Uses T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.
  • Definition ChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin.
  • General Description T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.
  • Safety Profile Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
T-2 TOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
T-2 TOXIN Suppliers
Global(130)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
  • Advantage：58
T-2 TOXIN Spectrum
21259-20-1, T-2 TOXINRelated Search:
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  • 4Β,15-二乙酰氧基-3Α-羟基-8Α-(3-甲基丁酰氧)-12,13-环氧单端孢霉-9-烯
  • 12,13-环氧单端孢霉-9-烯-3,4,8,15-四醇-4,15-二醋酸酯-8-异戊酸酯
  • T-2毒素
  • T-2毒素(镰刀菌属)
  • 21259-20-1
  • T2 Toxin in Acetonitrile
  • U-[13C24]-T-2 Toxin in Acetonitrile:Water
  • T-2 Toxin 100 μg/ml Acetonitrile
  • T-2 toxins
  • 13C24]-T-2 toxin-25 μg/mL in ACN
  • CAS21259-20-1 T-2 TOXIN
  • T-2 Toxin Solution in Acetonitrile, 100μg/mL
  • U-[13C24]-T-2 Toxin Solution in Acetonitrile, 25μg/mL
  • T2 toxin 100ug/ml in ACN
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3α,4β,8α)-
  • T-2 Toxin (T-2 Mycotoxin)
  • T-2 Toxin, 99%, from Fusarium tricinctum
  • 12,13-epoxytrichothec-9-ene-3alpha,4beta,8alpha,15-tetrol,4,15-diacetate8-isov
  • 12,13-epoxytrichothec-9-ene-3,4,8,15-tetrol4,15-diacetate8-(3-methylbutanoate
  • (3alpha,4beta,8alpha)-oate
  • (3α,4β,8α)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-Diacetate 8-(3-Methylbutanoate)
  • T-2 Toxin,12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate, 4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
  • Epoxytrichothecene, Fusariotoxin T 2, Mycotoxin T 2
  • 4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene, 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate
  • Fusariotoxin T2: (T2-Trichothecene)
  • (3-alpha, 4-beta, 8-alpha)-Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), Mycotoxin Trichothecene 2, Fusariotoxin
  • 12,13-EPOXYTRICHOTHECENE
  • T-2TRICHOTHECENE
  • 12,13-epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate
  • (3alpha,4beta,8alpha)-12,13-epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-diacetate 8-(3-methylbutyrate)
  • 100 ug/ml T-2 Toxin in ACN

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