Chemical Properties
Very soluble in methanol, ethanol, acetone and ethyl acetate, soluble in ethanol, acetic acid and chloroform, slightly soluble in benzene and water, insoluble in carbon disulfide and petroleum quartz. From the root of Scutellaria baicalensis Georgi, family Labiatae.
Uses
Wogonin acts as an anti-inflammatory agent, attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. In addition, it reverses multi-drug resistance of human myelogenous leukemia.
Definition
ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.
General Description
Wogonin is a flavonoid component of
Scutellaria baicalensis Georgi roots.
Biochem/physiol Actions
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.
storage
Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
