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WEDELOLACTONE

CAS No.524-12-9
Chemical Name:WEDELOLACTONE
CBNumber:CB1505300
Molecular Formula:C16H10O7
Formula Weight:314.25
MOL File:524-12-9.mol

WEDELOLACTONE Property

Melting point 327～330℃
Boiling point 498.4±45.0 °C(Predicted)
Density 1.655±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 14 mg/mL, soluble
form solid
pka 6.90±0.20(Predicted)
color brown-beige
InChIKey XQDCKJKKMFWXGB-UHFFFAOYSA-N
FDA UNII 0K6L725GNS
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xn
Risk Statements :22-43
Safety Statements :36/37
WGK Germany :3
HS Code :29322090

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P501

WEDELOLACTONE Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: W4016
Product name : Wedelolactone
Purity: ≥98% (HPLC), powder
Packaging: 1MG
Price: ₹16259.15
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: W0015
Product name : Wedelolactone
Purity:
Packaging: 1MG
Price: ₹4400
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: W0015
Product name : Wedelolactone
Purity:
Packaging: 10MG
Price: ₹10600
Updated: 2022/05/26
Buy: Buy

WEDELOLACTONE Chemical Properties,Usage,Production

Uses Wedelolactone is inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.
Definition ChEBI: A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.
Biological Activity wedelolactone is an inhibitor of ikk.ikb kinase (ikk) complex contains the catalytic subunits ikkα and ikkβ, and the regulatory subunit ikkγ/nemo. ikk, is a kinase critical for activation of nf-κb by mediating phosphorylation and degradation of iκbα. the induction of caspase-11 is an important upstream controlling event in inflammatory response and apoptosis under pathological conditions modulated by upstream nf-κb-mediated transcription[1].
Biochem/physiol Actions Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.
in vitro in cultured mouse balb/c 3t3 cells, mouse splenocytes and hela cells, wedelolactone (0~100 μm) inhibited lps-induced caspase-11 expression by inhibiting nf-κb-mediated transcription through the direct inhibition of ikk. wedelolactone played an potential role in anti-inflammatory therapy to inhibit il-1β levels in diseases such as rheumatoid arthritis, asthma and septic shock[1].
in vivo on swiss albino male mouse skin, ikk inhibition by wedelolactone (10 μm) prevented the induction of nf-κb, perturbed the generation of reactive oxygen species and reactive nitrogen intermediates, blunted the signal transduction that lead to the activation of the early immediate genes, and thereby protected mouse skin from the uvb induced neoplastic transformation, angiotropism and metastatic progression [2].
References [1] kobori m, yang z, gong d, et al. wedelolactone suppresses lps-induced caspase-11 expression by directly inhibiting the ikk complex.[j]. cell death & differentiation, 2004, 11(1):123-30.
[2] ali f, khan b a, sultana s. wedelolactone mitigates uvb induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of nfκb pathway[j]. european journal of pharmacology, 2016, 786:253-264.