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Pristinamycin IA

Pristinamycin IA Structure
Pristinamycin IA
  • CAS No.3131-03-1
  • Chemical Name:Pristinamycin IA
  • CBNumber:CB62079233
  • Molecular Formula:C45H54N8O10
  • Formula Weight:866.96
  • MOL File:3131-03-1.mol
Pristinamycin IA Property
  • Melting point 198°
  • alpha D22 -57.5° (c = 0.25 in ethanol)
  • Boiling point 780.3°C (rough estimate)
  • Density 1.1881 (rough estimate)
  • refractive index 1.6910 (estimate)
  • storage temp. -20°C Freezer
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka pKa 7.20±0.05(H2O,t =25,I=0.2(LiClO4)) (Uncertain)
  • color Pale Yellow
  • FDA UNII V50XJ0NC3I
Safety
  • RIDADR  :3172
  • HazardClass  :6.1(b)
  • PackingGroup  :III
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Pristinamycin IA Chemical Properties,Usage,Production

  • Uses Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a syngergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Viriginiamycin B acts a syngergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.
  • Uses One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810).
  • Definition ChEBI: A cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organis s including methicillin-resistant Staphylococcus aureus.
  • Contact allergens Pristinamycin is a systemic antibiotic of the synergistins/ streptogramins class, composed of two subunits: pristinamycin IA and pristinamycin IIA. It induces several types of drug reactions such as maculo-papular exanthema, systemic dermatitis, or acute generalized exanthematous pustulosis. Some patients have been previously skin-sensitized by virginiamycin. Crossreactivity is expected to virginiamycin and to the associated dalfopristin and quinupristin.
  • IC 50 Macrolide
Pristinamycin IA Preparation Products And Raw materials
Raw materials
Preparation Products
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Pristinamycin IA Spectrum
3131-03-1, Pristinamycin IARelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Chiral Reagents
  • 生化试剂
  • 标准品
  • 抑制剂
  • 微生物代谢物
  • C45H54N8O10
  • 131-03-1
  • 普利霉素IA,10 MM DMSO 溶液
  • 始霉素 IA
  • 弗吉尼亚霉素B
  • 始霉素 ⅠA
  • 维及霉素B
  • 化合物 T12540
  • N-(22-(4-(二甲氨基)苄基)-6-乙基-10,23-二甲基-5,8,12,15,17,21,24-庚氧基-13-苯基二十二氢-12H-吡啶基[2,1-F]吡咯[2,1-L][1]氧代[4,7,10,13,16]五氮杂环壬基-9-基)-3-羟基吡啶酰胺
  • 原始霉素IA
  • 普利霉素IA
  • 普那霉素IA, >95%
  • 普那霉素IA
  • 维吉霉素B
  • 3131-03-1
  • Pristinamycin IA, 10 mM in DMSO
  • Pristinamycin ⅠA
  • Antibiotic,ribosome,Bacterial,macrolactone,vinblastine,inhibit,Pristinamycin IA,Inhibitor,P-glycoprotein
  • Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-
  • Pristinamycin IA, >95%
  • MikaMycin IA
  • Antibiotic PA 114B1
  • Antibiotic PA 114B
  • 4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]virginiaMycin S1
  • PristinaMycin IA DISCONTINUED
  • Streptogramin B
  • Pristinamycin IA
  • Ostreogrycin B
  • N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo(L-Thr*-D-Abu-L-Pro-N-methyl-4-(dimethylamino)-L-Phe-4-oxo-L-2-piperidinecarbonyl-L-phenyl Gly-)
  • mikamycin B
  • VirginiaMycin B
  • Ostreogrycin B, PristinaMycin IA, StreptograMin B, Syncothrecin B1, Synergistin B, VernaMycin Balpha, VirginiaMycin 1A, NSC 125176, 14725-1, PA 114B, RP 12535
  • PristinaMycin P 1
  • PA 114B
  • NSC 92554
  • N-[(3-Hydroxy-2-pyridinyl)carbonyl]-L-threonyl-(2R)-2-aMinobutanoyl-L-prolyl-4-(diMethylaMino)-N-Methyl-L-phenylalanyl-(2S)-4-oxo-2-piperidinecarbonyl-(2S)-2-phenylglycine (6-13)-lactone

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