ChemicalBook > CAS DataBase List > Lisinopril Dihydrate

Lisinopril Dihydrate

CAS No.83915-83-7
Chemical Name:Lisinopril Dihydrate
CBNumber:CB3113756
Molecular Formula:C21H33N3O6
Formula Weight:423.51
MOL File:83915-83-7.mol

Lisinopril Dihydrate Property

Melting point 148 °C
alpha 25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); 25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)
refractive index -45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)
storage temp. 2-8°C
solubility H₂O: ≥10 mg/mL
pka 2.5, 4.0, 6.7, 10.1(at 25℃)
form solid
color white
Water Solubility H2O: ≥10mg/mL
DMSO: ~6.5mg/mL (with heating and sonicating)
Merck 14,5516
Stability Hygroscopic
CAS DataBase Reference 83915-83-7(CAS DataBase Reference)
NCI Dictionary of Cancer Terms lisinopril
FDA UNII E7199S1YWR
NCI Drug Dictionary lisinopril
ATC code C09AA03
EPA Substance Registry System L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2) (83915-83-7)
UNSPSC Code 41116107
NACRES NA.32

Safety

Hazard Codes :Xi,Xn
Risk Statements :20/21/22
Safety Statements :22-24/25-36
WGK Germany :3
RTECS :TW3589990
HazardClass :IRRITANT
HS Code :2933995300

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H360D-H373
Precautionary statements P202-P260-P280-P308+P313-P405-P501

Lisinopril Dihydrate Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: PHR1143
Product name : Lisinopril
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1G
Price: ₹11355.43
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: L6292
Product name : Lisinopril
Purity: ≥98% (HPLC)
Packaging: 100MG
Price: ₹43668.05
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: L6292
Product name : Lisinopril
Purity: ≥98% (HPLC)
Packaging: 250MG
Price: ₹88321.18
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: L0220
Product name : Lisinopril Dihydrate
Purity:
Packaging: 1G
Price: ₹5200
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: L0220
Product name : Lisinopril Dihydrate
Purity:
Packaging: 5G
Price: ₹11100
Updated: 2022/05/26
Buy: Buy

Lisinopril Dihydrate Chemical Properties,Usage,Production

Description Lisinopril is an angiotensin converting enzyme inhibitor structurally related to enalaprilat. It is reportedly useful in the management of hypertension and congestive heart failure.
Chemical Properties White to Off-White Crystalline Powder
Originator Merck (USA)
Uses An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril.
Uses These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Definition ChEBI: Lisinopril dihydrate is a hydrate. It has a role as an antihypertensive agent. It contains a lisinopril.
brand name Prinivil (Merck); Zestril (AstraZeneca).
General Description Lisinopril, 1-[N²-[S-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline dihydrate (Prinivil, Zestril), is alysine derivative of enalaprilat, the active metabolite ofenalapril. Like all ACE inhibitors, it is an active site-directedinhibitor of the enzyme, with the zinc ion used in an effectivebinding interaction at a stoichiometric ratio of 1:1. The pharmacologicaleffects of lisinopril are similar to those of captopriland enalapril.
Biochem/physiol Actions Angiotensin converting enzyme (ACE) inhibitor.
Clinical Use Many new ACE inhibitors became available for the treatmentof hypertension following the clinical effectivenessof enalapril. Enalapril is a non–thiol-containing ACE inhibitordevoid of the side effects of rash and loss of thesense of taste characteristic of the thiol-containing compoundcaptopril. With the exception of the phosphoruscontainingfosinopril, these antihypertensive agents havea 2-, like the prototypical drug captopril,are used in the treatment of mild-to-moderate hypertension,either alone or in conjunction with diuretics orcalcium channel blockers.
Veterinary Drugs and Treatments The principle uses of lisinopril in veterinary medicine at present are as a vasodilator in the treatment of heart failure or hypertension. Recent studies have demonstrated that ACE inhibitors, particularly when used in conjunction with furosemide, do improve the quality of life in dogs with heart failure. It is not clear, however, whether it has any significant effect on survival times. Lisinopril may also be of benefit in treating the effects associated with valvular heart disease (mitral regurgitation) and left to right shunts. It is being explored as adjunctive treatment in chronic renal failure and in protein losing nephropathies.
Lisinopril may have advantages over other ACE inhibitors in that it may be dosed once daily and less expensive. Disadvantages are that it is only available in human labeled dosage forms and there is much less published information on its use (efficacy, safety, dosing) in veterinary species.