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VIRGINIAMYCIN M1

VIRGINIAMYCIN M1 Structure
VIRGINIAMYCIN M1
  • CAS No.21411-53-0
  • Chemical Name:VIRGINIAMYCIN M1
  • CBNumber:CB3294594
  • Molecular Formula:C28H35N3O7
  • Formula Weight:525.59
  • MOL File:21411-53-0.mol
VIRGINIAMYCIN M1 Property
  • Melting point 165-167℃
  • alpha D20 -218° ( c = 0.34 in ethanol)
  • Boiling point 825.2±65.0 °C(Predicted)
  • Density 1.26±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility chloroform/methanol: soluble10mg/mL
  • form powder
  • pka 13.18±0.70(Predicted)
  • color yellow to tan
  • Stability Light Sensitive
  • FDA UNII 8W4UOL59AZ
Safety
  • WGK Germany  :3
  • HS Code  :29419090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P271-P280
VIRGINIAMYCIN M1 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: V2753
  • Product name : Virginiamycin M1
  • Purity: ≥95% (HPLC)
  • Packaging: 5MG
  • Price: ₹48560.95
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: V2753
  • Product name : Virginiamycin M1
  • Purity: ≥95% (HPLC)
  • Packaging: 10MG
  • Price: ₹56603.93
  • Updated: 2022/06/14
  • Buy: Buy

VIRGINIAMYCIN M1 Chemical Properties,Usage,Production

  • Chemical Properties Light yellow powder
  • Uses Macrolactone antibiotic. Antibacterial; growth promotant.
  • Uses Ostreogrycin A (virginiamycin M1, streptogramin A) is the major component of the virginiamycin complex. In the 1950s this complex was independently discovered so many times that the literature became highly confusing. Ostreogrycin A is a macrocyclic lactone antibiotic that acts synergistically with the structurally unrelated cyclic depsipeptides, virginiamycin B (ostreogrycin B, streptogramin B) and virginiamycin S, to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Ostreogrycin A is highly active against Gram positive bacteria, particularly MRSA.
  • Uses Ostreogrycin A (virginiamycin M1, streptogramin A) is the major component of the virginamycin complex. In the 1950s this complex was independently discovered so many times that the literature became highly confusing. Ostreogrycin A is a macrocyclic lactone antibiotic that acts synergistically with the structurally unrelated cyclic depsipeptides, virginiamycin B (ostreogrycin B, streptogramin B) and virginiamycin S, to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Ostreogrycin A is highly active against Gram positive bacteria, particularly MRSA.
  • Definition ChEBI: A macrolide that is (together with pristinamycin IA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organisms includ ng methicillin-resistant Staphylococcus aureus.
  • Biological Activity virginiamycin m1 is a macrolide antibiotic that reversibly inhibits protein synthesis [1][2][3].virginiamycin complex contains two antibiotics, virginiamycin m1 and virginiamycin s1. streptogramins are divided into class a and class b based on their structures. virginiamycin m1, also known as streptogramin a, is a member of the streptogramin a group of antibiotics, which bind the 50s ribosomal subunit at the peptidyl transferase center to inhibit initiation and translocation. they show good bactericidal activity against methicillin-resistant s. aureus (mrsa), although resistance in mrsa is conferred by the cfr gene. virginiamycin m1 has activity against gram-positive and in select cases gram-negative bacteria. combination of group a and b streptogramins exhibit bactericidal activity [1]. virginiamycin m1 acted synergistically with virginiamycin s1 to irreversibly inhibit protein synthesis in bacteria. in cell-free systems, virginiamycin m1 and virginiamycin s1 bound to the large ribosomal subunit, and the affinity of ribosomes for vs is increased by vm [2][3].
  • Contact allergens Pristinamycin is a systemic antibiotic of the synergistins/ streptogramins class, composed of two subunits: pristinamycin IA and pristinamycin IIA. It induces several types of drug reactions such as maculo-papular exanthema, systemic dermatitis, or acute generalized exanthematous pustulosis. Some patients have been previously skin-sensitized by virginiamycin. Crossreactivity is expected to virginiamycin and to the associated dalfopristin and quinupristin.
  • Contact allergens Like the other streptogramin, pristinamycin, virginiamycin is made of two subunits, virginiamycin S1 and virginiamycin M1. Dermatitis was quite common in people using the formerly available topical virginiamycin. Occupational dermatitis was observed in the pharmaceutical industry, in breeders, and in a surgeon who used topical virginiamycin on postoperative wounds (personal observation).
  • References [1]. fair rj, tor y. antibiotics and bacterial resistance in the 21st century. perspect medicin chem. 2014 aug 28;6:25-64.
    [2]. kehrenberg c, cuny c, strommenger b, et al. methicillin-resistant and -susceptible staphylococcus aureus strains of clonal lineages st398 and st9 from swine carry the multidrug resistance gene cfr. antimicrob agents chemother. 2009 feb;53(2):779-81.
    [3]. parfait r, cocito c. lasting damage to bacterial ribosomes by reversibly bound virginiamycin m. proc natl acad sci u s a. 1980 sep;77(9):5492-6.
VIRGINIAMYCIN M1 Preparation Products And Raw materials
Raw materials
Preparation Products
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VIRGINIAMYCIN M1 Spectrum
21411-53-0, VIRGINIAMYCIN M1Related Search:
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  • C28H35N3O7
  • 维吉尼亚霉素M1,10 MM DMSO 溶液
  • 乙腈中维吉尼霉素M1
  • 甲醇中维吉尼霉素M1
  • 甲醇中维吉尼亚霉素
  • (12Z,6R,7R,8E,13E,15E,17S)-17-羟基-6-异丙基-7,15-二甲基-32,33-二氢-31H-5-氧杂-11-氮杂-1(4,2)-恶唑-3(1,5)-吡咯环二十碳烷-8,13,15-三烯-2,4,10,19-四酮
  • 始霉素 ⅡA
  • 普那霉素ⅡA
  • 原始霉素IIA
  • 维吉霉素M1溶液,1000UG/ML
  • 甲醇中维吉尼霉素 M1, 维吉尼亚霉素M1
  • 维及霉素 M1
  • 维吉霉素M1溶液,100PPM
  • 维吉霉素M1 标准品
  • 普利霉素IIA
  • 维吉尼亚霉素M1, 来源于维吉尼亚链霉菌
  • 蛎灰菌素A
  • 蛎灰菌素
  • 维吉尼霉素 M1, 维吉尼亚霉素M1
  • 春霉素 A
  • 普那霉素IIA
  • 维吉霉素M1
  • 维吉尼亚霉素M1
  • 维吉尼霉素M1
  • 奥斯立星A
  • 21411-53-0
  • Virginiamycin M1, 10 mM in DMSO
  • Virginiamycin M1 in Methanol
  • (12Z,6R,7R,8E,13E,15E,17S)-17-Hydroxy-6-isopropyl-7,15-dimethyl-32,33-dihydro-31H-5-oxa-11-aza-1(4,2)-oxazola-3(1,5)-pyrrolacycloicosaphane-8,13,15-triene-2,4,10,19-tetraone
  • Pristinamycin IIA|||Ostreogrycin A
  • Lepidophorin A
  • Pristinamycin ⅡA
  • Streptogramin A
  • Pristinamycin IIAQ: What is Pristinamycin IIA Q: What is the CAS Number of Pristinamycin IIA Q: What is the storage condition of Pristinamycin IIA Q: What are the applications of Pristinamycin IIA
  • Virginiamycin M1 Solution in Methanol,1000ug/ml
  • 3H-21,18-Nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone, 8,9,14,15,24,25-hexahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-, (3R,4R,5E,10E,12E,14S)-
  • Virginiamycin M1, 98%, from Streptomyces virginiae
  • Verginiamycin M1 Ostreogrycin A Antibiotic PA 114A NSC 244426 NSC 87432
  • Pristinamycin II
  • PA 114A
  • NSC 87432
  • NSC 244426

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