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Virginiamycin

CAS No.11006-76-1
Chemical Name:Virginiamycin
CBNumber:CB9493027
Molecular Formula:C71H84N10O17
Formula Weight:1349.48346
MOL File:11006-76-1.mol

Virginiamycin Property

Melting point 170-178℃
storage temp. Amber Vial, Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Pale Yellow
Stability Hygroscopic, Light Sensitive
FDA 21 CFR 556.750; 558.635; 558.4
EWG's Food Scores 4
FDA UNII 4O8O7Q7IU4
ATC code D06AX10,J01FG01
EPA Substance Registry System Virginiamycin (11006-76-1)
UNSPSC Code 51283802
NACRES NA.76

Safety

HS Code :2941900000
Hazardous Substances Data :11006-76-1(Hazardous Substances Data)

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H317-H318
Precautionary statements P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P280-P305+P351+P338-P310

Virginiamycin Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: SBR00044
Product name : Pristinamycin
Purity: ≥98% (Assay)
Packaging: 5MG
Price: ₹14061.68
Updated: 2022/06/14
Buy: Buy

Virginiamycin Chemical Properties,Usage,Production

Description Mikamycin was found in the culture broth of Streptomyces mitakaensis by Umezawa et al. of the University of Tokyo in 1956. It is a mixture of two components, A and B, showing synergistic effects on each other. Staphylomycin, which was found by De Somer of Leuven University in 1955, is a closely related compound. Mikamycin shows strong activity against grampositive bacteria, including strains resistant to other antibiotics. It has been used topically to treat Staphylococcus or Streptococcusinfections of the skin, including burns.
Uses Virginiamycin complex is defined as a mixture of 75% ostreogrycin A (virginiamycin M1) and 25% virginiamycin S1, together with the less abundant S analogues. As the two major components have quite different solubilities, these proportions are not readily achieved or used. BioAustralis has isolated and re-combined the individual components to provide the defined components of virginiamycin complex. The composition of the complex is important as Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.
Uses Virginiamycin is a mixture of Virginiamycin S1 and Virginiamycin M1 (V673810). It is an antibiotic used in livestock feed to prevent disease among young swine. Also is used in ethanol production to prevent microbial contamination.
Uses Pristinamycin is a mixture of two components that have a synergistic antibacterial action. The two components are Pristinamycin IIA (V673810) and Pristinamycin IA (P745000).
Uses Occupational dermatitis was observed in the pharmaceutical industry and in a surgeon who used topical virginiamycin on postoperative wounds (CJ Le Coz, unpublished observations).
brand name Stafac (SmithKline Beecham Animal Health).
Pharmaceutical Applications A natural product of Streptomyces virginiae with antimicrobial activity similar to that of other streptogramins. It has chiefly been used as an animal feed additive, but is available in some countries for oral administration and in topical preparations.
Pharmaceutical Applications The two major components are pristinamycin IA and pristinamycin IB. It is available in some countries for the oral treatment of upper respiratory, bronchopulmonary, dental, skin, genital and bone infections caused by susceptible organisms. In-vitro activity is summarized in Table 28.1. The drug is usually well tolerated, although minor gastrointestinal disturbances and rash may occur.
Biological Activity virginiamycin complex is a a complex containing two streptogramin antibiotics.virginiamycin complex contains two streptogramin antibiotics, virginiamycin m1 (75%) and virginiamycin s1 (25%), produced by s. virginiae.
Contact allergens Like the other streptogramin, pristinamycin, virginiamycin is made of two subunits, virginiamycin S1 and virginiamycin M1. Dermatitis was quite common in people using the formerly available topical virginiamycin. Occupational dermatitis was observed in the pharmaceutical industry, in breeders, and in a surgeon who used topical virginiamycin on postoperative wounds (personal observation).
Safety Profile Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Used as an antibiotic.
in vitro previous study found that the m1 and s1 components of virginiamycin (vm and vs) could inhibit protein synthesis in bacteria--reversibly when a single component was present and irreversibly when both were present. in cell-free systems, each factor bound to the large ribosomal subunit, and the affinity of ribosomes for vs was enhanced in the presence of vm. in addition, the binding of labeled vm to ribosomes yielded particles unable to perform poly(u)-directed polyphenylalanine synthesis. moreover, the association constant for the binding of vs to these particles was equal to that incubated with a mixture of vm and vs [1].
in vivo a radiochemical method was developed to estimate cholyltaurine hydrolase potentials and rates of cholyltaurine hydrolysis in chicken intestinal homogenates. this method was used to monitor the effects of antibiotic feed additives on cholyltaurine hydrolase activity. results showed that virginiamycin could improve the rate of weight gain and feed conversion and decrease cholyltaurine hydrolase activity in ileal homogenates relative [2].
References 1. parfait, r., and cocito, c. lasting damage to bacterial ribosomes by reversibly bound virginiamycin m. proceedings of the national academy of sciences of the united states of america 77(9), 5492-5496 (1980).2. feighner, s.d., and dashkevicz, m.p. subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity. applied and environmental microbiology 53(2), 331-336 (1987).