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Ethyl isocyanoacetate

Ethyl isocyanoacetate Structure
Ethyl isocyanoacetate
  • CAS No.2999-46-4
  • Chemical Name:Ethyl isocyanoacetate
  • CBNumber:CB7209404
  • Molecular Formula:C5H7NO2
  • Formula Weight:113.11
  • MOL File:2999-46-4.mol
Ethyl isocyanoacetate Property
  • Boiling point 194-196 °C (lit.)
  • Density 1.035 g/mL at 25 °C (lit.)
  • vapor pressure 61.7Pa at 25℃
  • refractive index n20/D 1.418(lit.)
  • Flash point 184 °F
  • storage temp. 2-8°C
  • solubility Chloroform, Methanol (Slightly)
  • form Liquid
  • color Clear amber to dark brown
  • Water Solubility Miscible with organic solvents. Slightly miscible with water.
  • Sensitive Moisture & Light Sensitive
  • BRN 3588613
  • Exposure limits NIOSH: IDLH 25 mg/m3
  • LogP 0.91 at 25℃
  • CAS DataBase Reference 2999-46-4(CAS DataBase Reference)
  • UNSPSC Code 12352100
  • NACRES NA.22
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302+H332
  • Precautionary statements P261-P264-P270-P271-P301+P312-P304+P340+P312
Ethyl isocyanoacetate Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: 226319
  • Product name : Ethyl isocyanoacetate
  • Purity: 95%
  • Packaging: 5G
  • Price: ₹6949.65
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 226319
  • Product name : Ethyl isocyanoacetate
  • Purity: 95%
  • Packaging: 25G
  • Price: ₹23641.8
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: I0562
  • Product name : Ethyl Isocyanoacetate
  • Purity: min. 97.0 %
  • Packaging: 5G
  • Price: ₹7300
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: I0562
  • Product name : Ethyl Isocyanoacetate
  • Purity: min. 97.0 %
  • Packaging: 25G
  • Price: ₹19500
  • Updated: 2022/05/26
  • Buy: Buy

Ethyl isocyanoacetate Chemical Properties,Usage,Production

  • Chemical Properties Light yellow to brom liquid. Slightly soluble in water and lye, miscible in ethanol and ether.
  • Uses Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.
  • Uses Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.
  • Preparation synthesis of ethyl isocyanoacetate
    A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).
  • General Description Material may darken upon storage
Ethyl isocyanoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl isocyanoacetate Suppliers
Global(246)Suppliers
  • Supplier：
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Ethyl isocyanoacetate Spectrum
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