ChemicalBook > CAS DataBase List > Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Structure
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
  • CAS No.176199-48-7
  • Chemical Name:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
  • CBNumber:CB61042715
  • Molecular Formula:C8H11NO4
  • Formula Weight:185.18
  • MOL File:176199-48-7.mol
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Property
  • Melting point 270-271 °C
  • Boiling point 376.4±32.0 °C(Predicted)
  • Density 1.569
  • storage temp. Keep in dark place,Sealed in dry,2-8°C
  • solubility H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming)
  • form Powder
  • pka 2.06±0.40(Predicted)
  • color White to off-white
  • FDA UNII ONU5A67T2S
  • UNSPSC Code 12352200
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 5.04685
  • Product name : LY 354740 - CAS 176199-48-7 - Calbiochem
  • Purity: 
  • Packaging: 10MG
  • Price: ₹14590
  • Updated: 2022/06/14
  • Buy: Buy

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Chemical Properties,Usage,Production

  • Uses LY 354740 is a highly selective and potent agonist of group II mGluR.
  • Uses Treatment ofgeneral anxiety disorders and smoking cessation (metabotropic glutamate agonist).
  • Definition ChEBI: Eglumetad is a L-alpha-amino acid.
  • Biological Activity Highly selective and potent agonist of group II mGlu receptors (EC 50 values are 5.1 and 24.3 nM at mGlu 2 and mGlu 3 receptors respectively and > 100000 nM at mGlu 4 , mGlu 7 , mGlu 1a and mGlu 5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.
  • in vivo

    Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) has no effect on spatial working memory performance in Gria1 / or WT mice, and it has no effect on rewarded alternation testing with a short inter-trial interval in Gria1 / and WT mice at concentration of 30 mg/kg. Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) reduces spontaneous locomotor activity in wild-type and Gria1 / mice[1]. Eglumegad (LY354740) (15 mg/kg, i.p.) dreases novelty-induced hyperlocomotion in naive GluA1-KO and pre-handled GluA1-KO males, but not in females. Eglumegad (LY354740) (15 mg/kg, i.p.) significantly reduces the increased c-Fos expression of GluA1-KO males to the level of WT males, but not in of females[3]. Eglumegad (LY354740) (10 mg/kg, i.p.) attenuates the immobilization stress-induced increase in BDNF mRNA expression in the rat mPFC[4].

  • IC 50 mGluR2R: 5 nM (IC50); mGluR3R: 24 nM (IC50)
  • storage +4°C
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Suppliers
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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Spectrum
176199-48-7, Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)Related Search:
  • Glutamate
  • CYCLOPENTANE
  • 抑制剂
  • LY 354740,GROUP II MGLU激动剂
  • 化合物 EGLUMEGAD
  • EGLUMETAD|||LY354740
  • (1S,2S,5R,6S)-2-氨基双环[3.1.0]己烷-2,6-二羧酸
  • (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸
  • 176199-48-7
  • LY 354740, Group II mGlu agonist
  • Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S...
  • Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)-
  • Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]-
  • (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
  • LY 354740
  • Eglumetad
  • Eglumegad
  • Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

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