Chemical Properties
PALE BROWN TO BROWN CRYSTALLINE POWDER
Uses
Pramoxine impurity. Phenol derivatives induced tumor cell apoptosis.
Uses
Intermediates of Liquid Crystals
Uses
It is an intermediate of liquid crystals.
Definition
ChEBI: 4-Butoxyphenol is an aromatic ether.
Synthesis
General procedure for the synthesis of 4-n-butoxyphenol from 1-butoxy-4-iodobenzene: To a stirred solution containing CuI (19.0 mg, 10 mol%) and dimethylethylenedioxime (L6; 23.2 mg, 20 mol%) were added, in order, aryl halide (1 mmol), CsOH (3 mmol), and H2O (1 mL) over a period of 0.1 hours. The reaction mixture was stirred in DMSO (1 mL) at 120 °C (for aryl iodides) or the corresponding temperature (for aryl bromides). The reaction progress was monitored by TLC (EtOAc-hexane). Upon completion of the reaction, the mixture was cooled to room temperature and acidified with 0.5 M HCl (0.5 mL). The resulting mixture was extracted with EtOAc (3 × 10 mL) and the organic phase was dried with Na2SO4. After evaporation of the solvent, the residue obtained was purified by column chromatography.
References
[1] Journal of Chemical Sciences, 2018, vol. 130, # 2,
