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NVP-LDE225

NVP-LDE225 Structure
NVP-LDE225
  • CAS No.956697-53-3
  • Chemical Name:NVP-LDE225
  • CBNumber:CB52515129
  • Molecular Formula:C26H26F3N3O3
  • Formula Weight:485.5
  • MOL File:956697-53-3.mol
NVP-LDE225 Property
  • Melting point 154-157°C
  • Boiling point 544.5±50.0 °C(Predicted)
  • Density 1.255
  • storage temp. Refrigerator
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form White solid.
  • pka 9.53±0.70(Predicted)
  • color Light Purple
  • NCI Dictionary of Cancer Terms erismodegib; LDE225
  • FDA UNII 0RLU3VTK5M
  • NCI Drug Dictionary sonidegib
  • ATC code L01XJ02
Safety
  • HS Code  :2934999090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P271-P280-P261

NVP-LDE225 Chemical Properties,Usage,Production

  • Uses A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.
  • Definition ChEBI: A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as it phosphate salt) for treatment of locally advanced basal cell carcinoma.
  • Biological Activity lde225 is a potent and selective inhibitor of smoothened with ic50 values of 1.3nm in mouse and 2.5nm in human, respectively [1].lde225 is screened out from a high-throughput cell-based screen of in-house diversity combinatorial libraries and is developed to be an antagonist of smo. smo is an activator of the hedgehog(hh) signaling pathway and aberrant activation links to tumorigenesis in several cancers. the antitumor efficacy of lde225 has been evaluated in vivo. in the subcutaneous ptch+/-p53-/- medulloblastoma allograft mouse model, lde225 can significantly inhibit tumor growth at a dose of 5mg/kg/day. and in an orthotopic ptch+/-p53-/- medulloblastoma allograft model, lde225 is suggested to penetrate the blood-brain barrier in tumor-bearing animals and cause the tumor growth inhibition after 4 days of treatment. additionally, the preclinical safety assays show that lde225 has no genotoxicity and has good selectivity [1].
  • target human Hedgehog
  • storage Store at -20°C
  • References [1] shifeng pan, xu wu, jiqing jiang, et al. discovery of nvp-lde225, a potent and selective smoothened antagonist. acs med. chem. lett. 2010, 1: 130–134.
NVP-LDE225 Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-LDE225 Suppliers
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NVP-LDE225 Spectrum
956697-53-3, NVP-LDE225Related Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
  • Heterocycles
  • Chiral Reagents
  • Aromatics
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 药靶配体
  • FDA批准的配体
  • 药物中间体
  • 化学试剂
  • 医药原料
  • 有机中间体
  • 干细胞与Wnt信号
  • 医药原料药
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • C26H26F3N3O3
  • 化合物SONIDEGIB,10 MM DMSO 溶液
  • SONIDEGIB (NVP-LDE225,ERISMODEGIB),SMOOTHENED (SMO)拮抗剂
  • N-(6-(顺-2,6-二甲基吗啉基)吡啶-3-基)-2-甲基-4'-(三氟甲氧基)-[1,1'-联苯]-3-甲酰胺
  • LDE225 (NVP-LDE225,ERISMODEGIB),SMOOTHENED(SMO)拮抗剂
  • (磷酸索立德吉)
  • 化合物SONIDEGIB
  • 索尼地吉/LDE225
  • LDE225游离态
  • REL-N-[6-[(2R,6S)-2,6-二甲基-4-吗啉基]-3-吡啶基]-2-甲基-4'-(三氟甲氧基)-[1,1'-联苯]-3-甲酰胺
  • LDE225 (NVP-LDE225,ERISMODEGIB)/索尼吉布
  • 索尼吉布
  • 索尼德吉
  • 索尼地吉
  • 956697-53-3
  • N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
  • Sonidegib, 10 mM in DMSO
  • Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist
  • LDE-225 (SONIDEGIB)
  • Sonidegib Erismodegib LDE225 LDE-225
  • N-(6-(cis-2,6-Dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
  • Sonidegib
  • LDE225
  • Erismodegib
  • CS-65
  • Sonidegib HCL
  • N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-yl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
  • LDE225 (NVP-LDE225,Sonidegib)
  • Sonidegib-d4 (morphonyl D4)Q: What is Sonidegib-d4 (morphonyl D4) Q: What is the CAS Number of Sonidegib-d4 (morphonyl D4) Q: What is the storage condition of Sonidegib-d4 (morphonyl D4)
  • Sonidegib /Erismodegib
  • NVP-LDE225 USP/EP/BP
  • SONIDEGIB(LDE225)
  • Sonidegib (Erismodegib, NVP-LDE225)
  • Erismodegib (LDE225)
  • Sonidegib (LDE-225,NVP-LDE225)
  • NVP-LDE225,Sonidegib
  • Sonidegib (NVP-LDE225)
  • rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
  • NVP-LDE225
  • AZP-577

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