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Sodium Phosphate Monobasic Monohydrate

CAS No.10049-21-5
Chemical Name:Sodium Phosphate Monobasic Monohydrate
CBNumber:CB5158267
Molecular Formula:H4NaO5P
Formula Weight:137.992291
MOL File:10049-21-5.mol

Sodium Phosphate Monobasic Monohydrate Property

Melting point 100°C -H₂O
Boiling point 399 °C
Density 2,04 g/cm³
bulk density 880kg/m3
storage temp. Store at +5°C to +30°C.
solubility H₂O: 1 M, clear, colorless
form Solid
pka 7.21
color White semi-transparentor
PH 4.1-4.5 (25℃, 50mg/mL in H2O)
Odor Odorless
PH Range 4.1 - 4.5 at 50 g/l at 25 °C
Water Solubility Soluble in water; insoluble in ethanol, ether and chloroform.
Sensitive Hygroscopic
λmax λ: 260 nm Amax: ≤0.03
λ: 280 nm Amax: ≤0.02
Merck 14,8660
InChIKey BBMHARZCALWXSL-UHFFFAOYSA-M
LogP -2.148 (est)
CAS DataBase Reference 10049-21-5(CAS DataBase Reference)
FDA 21 CFR 310.545
FDA UNII 593YOG76RN
EPA Substance Registry System Monosodium phosphate monohydrate (10049-21-5)
Absorption ≤0.01 at 260nm
≤0.01 at 280nm
UNSPSC Code 41171610
NACRES NB.79

Safety

Hazard Codes :Xi
Risk Statements :36/37/38-36
Safety Statements :26-36/37/39-36-39-24/25
WGK Germany :1
RTECS :WA1900000
F :3
TSCA :Yes
HS Code :2835 22 00
Toxicity :LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 7940 mg/kg

NFPA 704:

	0
2		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Sodium Phosphate Monobasic Monohydrate Price More Price(31)

Brand: Sigma-Aldrich(India)
Product number: S9638
Product name : Sodium phosphate monobasic monohydrate
Purity: ACS reagent, ≥98%
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Brand: Sigma-Aldrich(India)
Product number: S9638
Product name : Sodium phosphate monobasic monohydrate
Purity: ACS reagent, ≥98%
Packaging: 250G
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Brand: Sigma-Aldrich(India)
Product number: S9638
Product name : Sodium phosphate monobasic monohydrate
Purity: ACS reagent, ≥98%
Packaging: 500G
Price: ₹12670
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Brand: Sigma-Aldrich(India)
Product number: S9638
Product name : Sodium phosphate monobasic monohydrate
Purity: ACS reagent, ≥98%
Packaging: 1KG
Price: ₹21170
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: S9638
Product name : Sodium phosphate monobasic monohydrate
Purity: ACS reagent, ≥98%
Packaging: 3KG
Price: ₹61442.7
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Sodium Phosphate Monobasic Monohydrate Chemical Properties,Usage,Production

Description Sodium Phosphate Monobasic Monohydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. it can be used as a buffer to adjust pH. In medicine, it is sometimes used as a stimulant laxative before certain operations and medical procedures. Sodium Phosphate Monobasic Monohydrate is often used in foods and in water treatment. It is used as sequestrant, emulsifier, mordant in dyeing, reagent and buffer in foods and analytical chemistry. It is applied as a fireproofing agent and for weighting silk in tanning. It is employed in manufacturing of enamels, ceramics, detergents, boiler compounds, in soldering and brazing instead of borax.
Monobasic sodium phosphate is used in baking powders, acid cleansers, electroplating, as a dry acidulant, and in treating boiler water.
Chemical Properties Anhydrous salt: white crystalline powder; slightly hygroscopic; forms sodium acid pyrophosphate, Na2H2P2O7 on heating above 225°C and sodium metaphosphate (NaPO3)n at about 350 to 400°C; very soluble in water, aqueous solution acidic.
Monohydrate: white orthorhombic crystals or granules; density 2.04 g/cm3 ; loses its water of crystallization at 100°C; very soluble in water, pH of 1% solution 4.5; insoluble in alcohol.
Dihydrate: large transparent crystals; orthorhombic bisphenoidal structure; density 1.915 g/cm 3 ; decomposes at 60°C; very soluble in water; insoluble in alcohol.
Chemical Properties The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.
Uses Sodium Phosphate Monobasic Monohydrate is often used in foods and in water treatment. it can be used as a buffer to adjust pH. In medicine, it is sometimes used as a stimulant laxative before certain operations and medical procedures.
Uses Excipient.
Uses Sodium phosphate monobasic monohydrate has been used for the preparation of cardioplegia solution. It has also been used as a component in McIlvaine′s buffer and MgCl₂ buffer.
Definition ChEBI: Sodium dihydrogenphosphate monohydrate is a hydrate that is the monohydrate form of sodium dihydrogenphosphate. It contains a sodium dihydrogenphosphate.
Preparation Monobasic sodium phosphate can be prepared by partial neutralization of phosphoric acid with sodium hydroxide in equimolar amounts:
H3PO4+ NaOH →NaH2PO4+ H2O
It also can be made by treating disodium hydrogen phosphate with phosphoric acid in proper stoichiometric amount:
Na2HPO4+ H3PO4→2NaH2PO4
Production Methods Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.
General Description Useful in conjuction with sodium phosphate, dibasic (Cat. No. 567550) in the preparation of biological buffers(absorbance: ≤0.01 at 260 nm and 280 nm).
Pharmaceutical Applications Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.
Safety Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg
storage Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.
Incompatibilities Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.
Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.