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10049-21-5

Supplier Related Products Identification Chemical Properties Safety Data Hazard Information Questions and Answers (Q&A) Well-known Reagent Company Product Information

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Identification

Name
PHOSPHATE BUFFER
CAS
10049-21-5
Synonyms
BOD PHOSPHATE BUFFER SOLUTION A
BUFFER COLOUR CODED CONCENTRATED SOLUTION PH 7 (PHOSPHATE) YELLOW
BUFFER COLOUR CODED SOLUTION PH 7 (PHOSPHATE) YELLOW
BUFFER CONCENTRATE, PH 7 (PHOSPHATE)
BUFFER FOR BOD
BUFFER MDB 9.50
BUFFER PH 7.0 (PHOSPHATE)
BUFFER, PHOSPHATE
BUFFER, PHOSPHATE PH 6.8
BUFFER (PHOSPHATE), PH 7
BUFFER, PHOSPHATE PH 7.0
BUFFER, PHOSPHATE, PH 7.00
BUFFER PHOSPHATE, PH 7.20
BUFFER PHOSPHATE, PH 7.40
BUFFER SOLUTION PH 6 (PHOSPHATE)
BUFFER SOLUTION, PH 7.00 +/-0.02, YELLOW
BUFFER SOLUTION PH 7 (PHOSPHATE)
BUFFER SOLUTION, PHOSPHATE
BUFFER SOLUTION (PHOSPHATE), PH 7
BUFFER SOLUTION (PHOSPHATE), PH 7.20
EINECS(EC#)
231-449-2
Molecular Formula
H4NaO5P
MDL Number
MFCD00081857
Molecular Weight
137.992
MOL File
10049-21-5.mol

Chemical Properties

Appearance
white semi-transparent crystals or crystalline
Melting point 
100°C -H₂O
mp 
100°C-H₂O
Boiling point 
399 °C
density 
2,04 g/cm3
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: 1 M, clear, colorless

form 
Solid
color 
White semi-transparentor
Odor
Odorless
PH Range
4.1 - 4.5 at 50 g/l at 25 °C
PH
4.1-4.5 (25℃, 50mg/mL in H2O)
Water Solubility 
Soluble in water; insoluble in ethanol, ether and chloroform.
λmax
λ: 260 nm Amax: ≤0.03
λ: 280 nm Amax: ≤0.02
Sensitive 
Hygroscopic
Merck 
14,8660
InChIKey
BBMHARZCALWXSL-UHFFFAOYSA-M
Uses
Excipient.
CAS DataBase Reference
10049-21-5(CAS DataBase Reference)
EPA Substance Registry System
10049-21-5(EPA Substance)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
R36:Irritating to the eyes.
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing .
S39:Wear eye/face protection .
WGK Germany 
1

RTECS 
WA1900000

3
TSCA 
Yes
HS Code 
28352200
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 7940 mg/kg

Hazard Information

Description
Sodium Phosphate Monobasic Monohydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. it can be used as a buffer to adjust pH. In medicine, it is sometimes used as a stimulant laxative before certain operations and medical procedures. Sodium Phosphate Monobasic Monohydrate is often used in foods and in water treatment. It is used as sequestrant, emulsifier, mordant in dyeing, reagent and buffer in foods and analytical chemistry. It is applied as a fireproofing agent and for weighting silk in tanning. It is employed in manufacturing of enamels, ceramics, detergents, boiler compounds, in soldering and brazing instead of borax.
Monobasic sodium phosphate is used in baking powders, acid cleansers, electroplating, as a dry acidulant, and in treating boiler water.
Production Methods
Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.
General Description
Useful in conjuction with sodium phosphate, dibasic (Cat. No. 567550) in the preparation of biological buffers(absorbance: ≤0.01 at 260 nm and 280 nm).

Pharmaceutical Applications
Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.
Safety
Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg
storage
Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.
Incompatibilities
Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Questions and Answers (Q&A)

Chemical Properties
Anhydrous salt: white crystalline powder; slightly hygroscopic; forms sodium acid pyrophosphate, Na2H2P2O7 on heating above 225°C and sodium metaphosphate (NaPO3)n at about 350 to 400°C; very soluble in water, aqueous solution acidic.
Monohydrate: white orthorhombic crystals or granules; density 2.04 g/cm3 ; loses its water of crystallization at 100°C; very soluble in water, pH of 1% solution 4.5; insoluble in alcohol.
Dihydrate: large transparent crystals; orthorhombic bisphenoidal structure; density 1.915 g/cm 3 ; decomposes at 60°C; very soluble in water; insoluble in alcohol.
Preparation
Monobasic sodium phosphate can be prepared by partial neutralization of phosphoric acid with sodium hydroxide in equimolar amounts:
H3PO4+ NaOH →NaH2PO4+ H2O
It also can be made by treating disodium hydrogen phosphate with phosphoric acid in proper stoichiometric amount:
Na2HPO4+ H3PO4→2NaH2PO4

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