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Bucladesine sodium

Bucladesine sodium Structure
Bucladesine sodium
  • CAS No.16980-89-5
  • Chemical Name:Bucladesine sodium
  • CBNumber:CB8236166
  • Molecular Formula:C18H25N5NaO8P
  • Formula Weight:493.39
  • MOL File:16980-89-5.mol
Bucladesine sodium Property
  • Melting point >173°C (dec.)
  • storage temp. -20°C
  • solubility H2O: 50 mg/mL
  • form powder
  • color white
  • biological source synthetic (organic)
  • Water Solubility water: 1mg/mL
  • Merck 14,1463
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
  • InChIKey DBXVIQJWMFGXGO-AOTDUVMNNA-N
  • SMILES O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] |&1:1,2,10,13,r|
  • FDA UNII 4DZN2C97A7
  • UNSPSC Code 41106305
  • NACRES NA.77
Safety
  • Safety Statements  :24/25
  • WGK Germany  :2
  • RTECS  :ES5055500
  • F  :10-21
  • HS Code  :29349990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
Bucladesine sodium Price More Price(15)
  • Brand: Sigma-Aldrich(India)
  • Product number: D0627
  • Product name : N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
  • Purity: ≥96% (HPLC), powder
  • Packaging: 25MG
  • Price: ₹7609.98
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D0627
  • Product name : N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
  • Purity: ≥96% (HPLC), powder
  • Packaging: 100MG
  • Price: ₹18012.8
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D0627
  • Product name : N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
  • Purity: ≥96% (HPLC), powder
  • Packaging: 250MG
  • Price: ₹34499.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D0627
  • Product name : N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
  • Purity: ≥96% (HPLC), powder
  • Packaging: 1G
  • Price: ₹105576.23
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D0627
  • Product name : N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
  • Purity: ≥96% (HPLC), powder
  • Packaging: 5X1G
  • Price: ₹345826.28
  • Updated: 2022/06/14
  • Buy: Buy

Bucladesine sodium Chemical Properties,Usage,Production

  • Description Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.
  • Originator Daiichi Seiyaku; Seishin Seiyaku (Japan)
  • Uses Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.
  • Definition ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.
  • Application N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
    as a medium supplement for neural crest stem cells (NCSCs) differentiation
    as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
    in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation
  • brand name ACTOCIN
  • General Description A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
  • Biochem/physiol Actions Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).
  • storage Store at -20°C
  • References 1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?1321
    2) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?511
    3) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?233
    4) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?6139
    5) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270
Bucladesine sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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Bucladesine sodium Spectrum
16980-89-5, Bucladesine sodiumRelated Search:
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