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LAVENDUSTIN C

LAVENDUSTIN C Structure
LAVENDUSTIN C
  • CAS No.125697-93-0
  • Chemical Name:LAVENDUSTIN C
  • CBNumber:CB5135705
  • Molecular Formula:C14H13NO5
  • Formula Weight:275.26
  • MOL File:125697-93-0.mol
LAVENDUSTIN C Property
  • Melting point 193-195°C dec.
  • Boiling point 597.5±50.0 °C(Predicted)
  • Density 1.551±0.06 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility DMSO: soluble
  • form solid
  • pka 2.32±0.10(Predicted)
  • color Light Beige to Brown
  • Stability Hygroscopic
  • FDA UNII HJM06BIW5M
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H319-H315
  • Precautionary statements P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

LAVENDUSTIN C Chemical Properties,Usage,Production

  • Description Lavendustin C, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 μM. Lavendustin C also inhibits pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II with IC50 values of 0.5 and 0.2 μM, respectively. At a concentration of 10-150 μM, lavendustin C inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.
  • Chemical Properties Brown Solid
  • Uses Shows potent tyrosine kinase inhibitory activity.
  • Definition ChEBI: 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid is an aromatic amine.
  • IC 50 CaMK II: 0.2 μM (IC50); EGFR: 0.012 μM (IC50)
LAVENDUSTIN C Preparation Products And Raw materials
Raw materials
Preparation Products
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LAVENDUSTIN C Spectrum
125697-93-0, LAVENDUSTIN CRelated Search:
  • Tyrosine Kinase Inhibitors
  • Inhibitors
  • All Inhibitors
  • Other enzyme inhibitors and activators
  • 抑制剂
  • Biochemicals and Reagents
  • BioChemical
  • Cell Biology
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Enzymes, Inhibitors, and Substrates
  • Kinase/Phosphatase Biology
  • Tyrosine Kinase (TK)
  • Receptor Tyrosine Kinase Inhibitors
  • Cell Signaling and Neuroscience
  • Chelators
  • N-(2,5-二羟基苄基)-5-氨基水杨酸,10 MM DMSO 溶液
  • 薰草菌素C
  • N-(2,5-二羟基苄基)-5-氨基水杨酸
  • 5-(2,5-二羟基苄基氨基)水杨酸
  • 5-(2,5-二羟基苄基氨基)-2-羟基苯甲酸
  • 125697-93-0
  • lavendustin C, 10 mM in DMSO
  • HER1,ErbB-1,EGFR,inhibit,Inhibitor,Calmodulin-dependent protein kinases,calmodulin-dependent,Src,lavendustin C,pp60,CaMK,Ca2+,Epidermal growth factor receptor,tyrosine,kinase,Calmodulin-dependent kinases
  • N-(2-((2-((4Z,7Z,10Z,13Z,16Z,19Z)-DOCOSA-4,7,10,13,16,19-HEXAENAMIDO)ETHYL)DISULFANYL)-2-METHYLPROPYL)NICOTINAMIDE
  • Lavendustin C (HDBA)
  • Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-
  • N-(2',5'-DIHYDROXYBENZYL)-5-AMINOSALICYLIC ACID
  • LAVENDUSTIN C
  • COMPOUND 5
  • HDBA
  • 5-(N-2,5-DIHYDROXYBENZYL)AMINOSALICYLIC ACID
  • 5-(N-2',5'-DIHYDROXYBENZYL)AMINOSALICYLIC ACID
  • 5-(2,5-DIHYDROXYBENZYLAMINO)SALICYLIC ACID
  • 5-(2,5-DIHYDROXYBENZYLAMINO)-2-HYDROXYBENZOIC ACID
  • [2-HYDROXY-5-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOIC ACID
  • 2-HYDROXY-5-(2,5-DIHYDROXYBENZYLAMINO)BENZOIC ACID
  • NSC 666251
  • 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxy-benzoic acid
  • 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid
  • 5-(2,5-Dihydroxybenzylamino)salicylic acid, N-(2,5-Dihydroxybenzyl)-5-aminosalicylic acid
  • Compound 5, HDBA, N-(2μ,5μ-Dihydroxybenzyl)-5-aminosalicylic acid, [2-Hydroxy-5-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoic acid
  • 2-hydroxy-5-(2,5-dihydrobenzyl)aminobenzoic acid

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