125697-93-0

Brown Solid

Shows potent tyrosine kinase inhibitory activity

Lavendustin C, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC₅₀ value of 0.012 μM. Lavendustin C also inhibits pp60^c-src(+) kinase and Ca²⁺ calmodulin-dependent kinase II with IC₅₀ values of 0.5 and 0.2 μM, respectively. At a concentration of 10-150 μM, lavendustin C inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.

ChEBI: 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid is an aromatic amine.

CaMK II: 0.2 μM (IC₅₀); EGFR: 0.012 μM (IC₅₀)

[1] HELEN M. BURT  Hassan S  John K Jackson. Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor[J]. Journal of Leukocyte Biology, 1994, 55 1: 112-119. DOI: 10.1002/jlb.55.1.112